期刊文献+

抗SPAG9自身抗体在肿瘤患者外周血中表达分析 被引量:2

Research on expression of anti-SPAG9 autoantibody in peripheral blood of cancer patients
下载PDF
导出
摘要 目的通过对各种肿瘤患者血清中精子相关抗原9(SPAG9)自身抗体的检测初步了解肿瘤患者外周血中抗SPAG9自身抗体的表达情况。方法采用重组SPAG9建立ELISA检测肝癌、肺癌以及其他肿瘤患者血清中的抗SPAG9自身抗体水平,以了解SPAG9引起的肿瘤患者体液免疫反应。以健康对照组血清中抗SPAG9自身抗体OD值的均值加2倍SD作为阳性判断标准。结果 86例肿瘤患者血清中抗SPAG9自身抗体总体阳性率为32.6%,肝癌组阳性率为48.1%,肺癌组为16.2%,其他肿瘤组为40.8%。结论 SPAG9自身抗体在各种肿瘤患者外周血中均有不同程度的表达,值得进一步研究。 Objective To discuss the expression of anti-SPAG9 autoantibody in peripheral blood of cancer patients by testing the anti-SPAG9 autoantibody in serum of cancer patients.Methods ELISA built by SPAG9 recombinant protein for the detection the levels of serum SPAG9 antibodies in liver cancer,lung cancer and other cancers patients to monitor the immune response against SPAG9 in cancer patients.The positive criterion was titers above the mean±2 SD of the healthy sera.Results The total positive rate of 86 cancer patients was 32.6%;liver cancer group was about 48.1%;lung group was just 16.2% and others was 40.8%.Conclusion Anti-SPAG9 autoantibody expression in peripheral blood of various cancer patients with different degree which worthiness further study.
出处 《重庆医学》 CAS CSCD 北大核心 2012年第30期3141-3142,3145,共3页 Chongqing medicine
基金 湖南省科技计划基金资助项目(2009SK3092) 湖南省卫生厅计划基金资助项目(B2011-099)
关键词 精子相关抗原-9 肿瘤 自身抗体 SPAG-9 neoplasms autoantibodies
  • 引文网络
  • 相关文献

参考文献16

  • 1Suri A. Cancer testis antigens their importance in immu- notherapy and in the early detection of cancer[J]. Expert Opin Biol Ther, 2006,6 (3) : 379-389.
  • 2Fernandez-Madrid F. Autoantibodies in breast cancer se- ra:candidate biomarkers and reporters of tumorigenesis [J]. Cancer Lett,2005,230(2):187-198.
  • 3Lechpammer M, Lukac J, Lechpammer S, et al. Humoral immune response to p53 correlates with clinical course in colorectal cancer patients during adjuvant chemotherapy [J]. Int J Colorectal Dis,2004,19(1) :114-120.
  • 4Casiano CA, Varela MM,Tan EM. Tumor-associated an- tigen arrays for the serological diagnosis of cancer[J]. Mol Cell Proteomies, 2006,5(14) : 1745-1759.
  • 5Stockert E,Jager E,Chen YT,et al. A survey of the hu- moral immune response of cancer patients to a panel of human tumor antigens[J]. J Exp Med, 1998, 187 (10) : 1349-1354.
  • 6Mischo A,Kubusehok B, Ertan K,et al. Prospective study on the expression of cancer testis genes and antibody re- sponses in 100 consecutive patients with primary breast cancer[J]. Int J Cancer, 2006,118 (5) : 696-703.
  • 7Jagadish N, Rana R, Mishra D, et al. Characterization of immune response in mice to plasmid DNA encoding hu- man sperm associated antigen 9 (SPAG9) [J]. Vaccine, 2006,214 (25):3695-3703.
  • 8Shankar S, Mohapatra B, Suri A. Cloning of a novel hu- man testis mRNA specifically expressed in testicular hap- loid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif [J]. Biochem Biophys Res Commun, 1998,243(4) : 561-563.
  • 9Jagadish N, Rana R, Selvi R, et al. Characterization of a novel human sperm-associated antigen 9 (SPAGg) having structural homology with c-Jun N-terminal kinase-interac- ting protein[J]. Biochem J,2005,389 (1) :73-82.
  • 10Stone B, Schummer M, Paley P J, et al. Serologic analysis of ovarian tumor antigens reveals a bias toward antigens encoded on 17q[J]. Int J Cancer, 200a, 104(1) : 73-84.

同被引文献7

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部