肠内营养联用枯草杆菌二联活菌肠溶胶囊防治重症急性胰腺炎肠道菌群失调

Prevention and treatment of combination of enteral nutrition and combined Bacillus Subtilis and enterococcus Faecium for alteration of intestinal flora after severe acute pancreatitis

目的探讨肠内营养联用枯草杆菌二联活菌肠溶胶囊对重症急性胰腺炎(SAP)患者肠道菌群失调的影响。方法重症急性胰腺炎患者105例随机分为肠外营养组、肠内营养组和肠内营养+枯草杆菌二联活菌肠溶胶囊组,检测治疗后3组肠道菌株的变化,比较肠道菌群失调症的发生情况。结果在SAP发病后7～10 d时,肠外营养组大肠埃希菌及肠球菌数量明显增加,而双歧杆菌和乳酸杆菌数量明显减少,肠内营养组和肠内营养+枯草杆菌二联活菌肠溶胶囊组患者大肠埃希菌及肠球菌数量明显减少,而双歧杆菌和乳酸杆菌数量明显增加,肠道菌群失调症发生率降低。结论肠内营养联用枯草杆菌二联活菌肠溶胶囊能减少SAP肠道菌群失调的发生。

Objective It is to evaluate the effect of combination of enteral nutrition and combined Bacillus Subtilis and enterococcus Faecium capsule on alteration of intestinal flora after severe acute pancreatitis（SAP）. Methods One hundred and thirty - five patients with SAP were randomly divided three groups ： parenteral nutrition group, enteral nutrition group, enteral nutrition group ＋ combined Bacillus Subtilis and enterococcus Faecium capsules group, and the changes of intestinal bacterial strains were measured, and the incidents of alteration of intestinal flora in the three group were compared. Results In seven - ten days later, quantities of Escherichia coli and enterococci of the parenteral nutrition group patients increased, while quantities of Bacillus bifidus and Bacillus acidi lactici decreased. Quantities of Escherichia coli and enterococci of the enteral nutrition group patients and enteral nutrition group ＋ combined Bacillus Subtilis and enterococcus Faecium capsules group decreased, while quantities of Bacillus bifidus and Bacillus acidi lactici increased, rate of incidents of alteration of intestinal flora decreased. Conclusion Combination of enteral nutrition group and combined Bacillus Subtilis and enterococcus Faecium capsules can decrease the incidents of alteration of intestinal flora after severe acute pancreatitis.