强心口服液对慢性心力衰竭患者血浆N末端B型利钠肽原浓度的影响

Effect of Qiangxin Oral Liquid to N-terminal Pro-brain B-type Natriuretic Peptides in Patients with Chronic Heart Failure

目的观察强心口服液对心力衰竭(CHF)患者血浆N末端B型利钠肽原(NT-proBNP)浓度的影响,比较西药常规治疗和中西医结合治疗的疗效差异。方法将51例NYHA心功能分级Ⅱ-Ⅳ级的CHF患者随机分为西药组和中西医结合组,分别予以西药常规治疗和西药常规治疗基础上加用强心口服液治疗;采用酶联免疫吸附法(ELISA)测定治疗前及治疗14d后血浆NT-proBNP浓度。结果经治疗后,两组血浆NT-proBNP浓度较治疗前均明显降低(P<0.05),且中西医结合组血浆NT-proBNP浓度较西药组降低更为明显(P<0.05),中西医结合治疗组综合疗效优于西药治疗组(P<0.05)。结论加用强心口服液的中西医结合治疗,能够显著降低血浆NT-proBNP浓度,改善心功能,其综合疗效优于西药常规治疗。

Objective To study the effect of Qiangxin Oral Liquid to N-terminal Pro-brain B-type Natriuretic Peptides（NT-proBNP）in Patients withChronic Heart Failure（CHF）;compare the differences between thera-peutic effects of western medicine regular therapy and conbined therapy of traditional Chinese Medicine and western medicine.Methods Including 51 patients with CHF（NYHA Ⅱ-Ⅳ）were randomly divided into western medicine regular therapy group and combined therapy of traditional Chinese medicine and western medicine group,respectively was treated by western medicine regular therapy and combined therapy of Qiangxin Oral Liquid and western medicine.The plasma concentration of NT-proBNP was determined by enzy-me-linked immunosorbent assay（ELISA）.Results After therapy,the plasma concentrations of NT-proBNP in two groups decreased significantly after therapy（P0.05） and the concentrations in combined therapy of traditional Chinese medicine and western medicine group were lower compared with western medicine regular therapy group（P0.05）;The therapeutic effects of combined therapy of traditional Chinese medicine and western medicine group are better than that of the western medicine regular therapy group（P0.05）.Conclusion sThe therapeutic effects of combined therapy of Qiangxin Oral Liquid and western medicine was better compared with western medicine regular therapy.