HIF-1α、MMP-9在胃腺癌组织中的表达及临床意义

The expression and clinical significance of HIF-1α、MMP-9 in gastric adencarcinoma

目的探讨胃腺癌组织中缺氧诱导因子-1α(HIF-1α)、基质金属蛋白酶-9(MMP-9)的表达及意义。方法对在该院进行手术切除63例患者采用免疫组织化学方法检测,分析HIF-1α、MMP-9蛋白在胃腺癌癌区组织、癌旁区组织、手术切缘区及正常组织等各区域的表达及意义。结果 HIF-1α、MMP-9蛋白在胃腺癌组织的阳性率明显高于癌旁区组织和正常组织,差异有统计学意义(P<0.05);在胃腺癌组织中,随着组织学病理分级的增加与临床分期的进展和淋巴结转移呈正相关,HIF-1α、MMP-9蛋白表达也随着临床分期进展和淋巴转移的转移阳性率逐渐上升,差异有统计学意义(P<0.05);HIF-1α、MMP-9蛋白表达具有相关性。结论 HIF-1α可能调控MMP-9的表达,两者联合检测可为胃腺癌的早期诊断、治疗、预后判断提供必要的理论依据。

Objectives Analyze the expression and clinical significance of hypoxia inducible fac-tor-1（HIF-1α）、matrix metallop roteinase-9（MMP-9） in gastric mucous adencarcinoma.Methods Using immunohistochemical method to localize and examine the expression of HIF-1α and MMP-9 in gastric mucous adencarcinoma,cancer surrounding tissue,operation incisal edge normal tissue,totally 63 examples.Results The expression of HIF-1α、MMP-9 were significantly increased in gastric mucous adencarcinoma compared with the cancer surrounding tissue and operation incisal edge normal tissue.The difference have significance（P0.05）.In gastric mucous adencarcinoma tissu,the expression of HIF-1αand MMP-9 were significantly increased with the increase of pathologic histology clinical stage and absorbent gland deadexis,the difference have significance（P 0.05）.The expression of HIF-1αand MMP-9 have dependablity.Conclusion HIF-1αcould control the expression of MMP-9.Association the detection of HIF-1αand MMP-9,that could provid essential theory employment of early diagnosis treatment and prognosis judgement.