摘要
目的探讨急性冠状动脉综合征介入术前应用他汀类药强化治疗的临床疗效。方法选取我院心内科2008年6月至2012年6月收治并确诊为急性冠状动脉综合征患者178例为研究对象,随机分为强化治疗组、常规治疗组各89例,按照不同方案口服他汀类药物,并同时检测术前及术后1d、3d、7d血清中C反应蛋白(CRP)水平,术前、术后血脂值,并进行系统比较。结果术前(CRP)水平、血脂值的比较无显著差异(P>0.05),术后比较有明显差异(P<0.05)。结论急性冠脉综合征是由于冠状动脉粥样斑块的不稳定、破裂导致炎症因子、血小板及凝血系统被激活,急性继发血栓形成,闭塞冠状动脉,冠状动脉血流急剧减少,从而造成心肌急性缺血、缺氧。包括不稳定性心绞痛(UAP)、ST段抬高及非ST段抬高心肌梗死。冠状动脉介入前强化口服他汀类药物阿托伐他汀,可明显降低术后血脂水平,增加斑块的稳定性,减轻炎症反应,改善内皮细胞功能,降低冠状动脉介入术后的并发症,提高手术成功率,值得在临床上推广。
Objective To explore the acute coronary syndrome interventional preoperative use of statins to strengthen the clinical efficacy of the treatment. Methods Department of cardiology in our hospital in 2008 June to 2012 year in June admits and diagnosed with acute coronary artery syndrome 178 cases as the object of study, were randomly divided into treatment group, routine treatment group with 89 cases in each group, ac- cording to the different regimens of oral statins, and simultaneous detection of preoperative and postoperative LD, 3 d, 7 d, CRP in scram reactive protein level, preoperative, postoperative lipid values, and a systematic comparison. Results of preoperative (CRP) levels, and lipid values showed no significant difference ( P 〉 0. 05 ), postoperative was significantly ( P 〈 0. 05 ). Conclusion Acute coronary syndrome due to coronary plaque instability, due to rupture of inflammatory cytokines, platclct and blood coagulation system was activa- ted, secondary to acute thrombosis, occlusion of the coronary artery, coronary artery blood flow decreased dra- matically, resulting in acute myocardial ischemia, hypoxia. Including unstable angina poctoris ( UAP), ST seg- ment elevation and non ST segment elevation myocardial infarction. Coronary intervention before intensive oral statins atorvastatin, can significantly reduce the postoperative serum lipid levels, increase plaque stability, re- duce inflammation, improve endothelial cell function after the operation of coronary artery intervention, reduce the complications, improve the success rate of operation, worthy of clinical popularization.
出处
《中国现代药物应用》
2012年第21期1-2,共2页
Chinese Journal of Modern Drug Application
关键词
急性冠状动脉综合征
介入术前
他汀类药物
强化治疗
Acute coronary syndrome
Interventional preoperative
Statin treatment
Strengthening