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强直性脊柱炎患者血清高迁移率族蛋白1水平及其意义 被引量:3

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摘要 目的通过检测强直性脊柱炎(AS)患者血清高迁移率族蛋白1(HMGB1)表达水平,探讨HMGB1与AS患者疾病活动性相关性。方法采用ELISA法测定51例AS患者和20位健康对照者血清HMGB1水平。收集AS患者的临床资料并测定相关实验室指标:疼痛视觉模拟评分(VAS)、疲乏VAS、患者对疾病总体状况的VAS(PGA)、健康评估问卷(HAQ),检测ESR、CRP。AS功能情况采用Bath强直性脊柱炎功能指数(BASFI)、Bath强直性脊柱炎疾病活动指数(BASDAI)评估方法,分析以上指标与血清HMGB1的相关性。结果 AS组血清HMGB1表达水平显著高于健康对照组,两组比较差异有统计学意义。AS患者血清HMGB1表达水平与ESR、BASDAI正相关,与疼痛VAS、疲乏VAS、PGA、HAQ、CRP无相关。结论活动期AS患者血清HMGB1表达水平明显升高,可能与疾病活动有关。
出处 《中国现代药物应用》 2012年第21期45-46,共2页 Chinese Journal of Modern Drug Application
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同被引文献42

  • 1古洁若,张汉伟,赵丽珂,黄烽,颜光美,余得恩.基质金属蛋白酶-3在强直性脊柱炎中的作用和意义探讨[J].中国药物与临床,2004,4(4):270-276. 被引量:14
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