农村妇女宫颈病变筛查及Id1的检测

Cervical Diasease Screening and ID1 Detection in Rural Women

目的对青岛市崂山区农村户籍妇女进行宫颈病变筛查．并检测宫颈上皮内瘤变（CIN）组织中细胞分化抑制因子（Id1）的表达。方法对辖区内适龄农村户籍妇女．先采用液基细胞学系统（LCT）检测，将LCT异常患者全部进行宫颈活检术，对CIN和宫颈癌组织进一步进行Id1蛋白表达的免疫组织化学检测和分析。结果8000名受检者中LCT异常者共121例，这些患者阴道镜下宫颈活检术结果显示共有62例组织学异常，其中轻度不典型增生（CINI）17例，中度不典型增生（CINII）14例，重度不典型增生（CINIII）28例，早期宫颈浸润癌（ICC）3例。上述组织中Id1有不同程度的表达：IcC〉CINIII〉CINII〉CINI。结论Id1的检测有助于宫颈病变的预后分析。

Objective In Laoshan district of Qingdao, cervical disease screening was performed in rural women and the inhibitor of DNA bingdingl（Idl） was detected in cervical intraepithelial neoplasia （CIN）. Methods Cervical disease screening was performed in 8000 rural women aged 35-59 years by liquid-based cytology test （LCT）firstly. Biopsy under colposcope was performed in women with LCT abnormality. The expression of Idl was detected by immunochenmistry in the tissues of CIN and cervical cancer. Results Among 8000 subjects, totally 121 cases were abnormal detected by LCT. In 121 eases, 62 cases were abnormal with cervical biopsy. Among them, 17cases were CINI, 14 cases were CIN lI, 28 cases were CINIII and 3 cases were early invasive cervical carcinoma （ICC）. The expression of Idl protein in above tissues was difference as： ICC〉CINIII〉CINII〉CINI. Conclusion The detection of Idl will be helpful for the prognosis assessment of cervical disease.