微小核糖核酸-25用于胃癌诊断及判断预后的意义

Prognostic Significance of miRNA-25 in Diagnosis and Judgment of Gastric Cancer

目的探讨微小核糖核酸-25(miRNA-25)对于胃癌患者的危险性判断及预后评估的临床意义。方法纳入2010年2月—2011年2月我院收治的72例胃癌的临床资料,并进行电话随访。根据患者预后分为未转移组和转移组,通过组间单因素比较及多因素Logistic回归分析等方法评价各因素与胃癌预后的相关性。结果本研究共纳入69例胃癌,在年龄、性别、吸烟史、miRNA-25、CA19-9方面转移组与未转移组比较,差异均有统计学意义。经Logistic回归分析结果显示年龄[OR=1.04,95%可信区间(CI):1.01～1.08,P<0.01]、男性所占比例(OR=1.05,95%CI:1.02～1.09,P<0.01)、吸烟史(OR=1.33,95%CI:1.27～1.48,P<0.01)、miRNA-25(OR=1.14,95%CI:1.09～1.22,P<0.01)、CA19-9(OR=1.29,95%CI:1.13～1.44,P<0.01)与患者预后存在显著相关性。通过工作特征(ROC)曲线检验miRNA-25的预测效能,计算曲线下面积为0.855(95%CI:0.818～0.892,P<0.01)。结论 miRNA-25可作为胃癌的独立诊断因素,将该指标纳入胃癌的诊断评测体系可进一步增强评估该病风险和预后的能力。

Objective To explore clinical significance of miRNA-25 in risk factors and prognosis evaluation of patients with gastric cancer.Methods Clinical data of 72 patients with gastric cancer admitted to our hospital during February 2010 and February 2011 according to prognosis were divided into non-metastasis group and metastasis group and followed up via telephone.The correlation of various factors and prognosis of gastric cancer were evaluated by comparing single factor and multivariate logistic regression analysis in the two groups.Results The differences in age,gender,smoking history,miRNA-25 and CA19-9 in 69 patients with gastric cancer of the two groups were statistically significant.Logistic regression analysis showed that age（OR=1.04,95% CI：1.01~1.08,P0.01）,male proportion（OR=1.05,95%CI： 1.02~1.09,P0.01）,and a smoking history（OR=1.33,95%CI： 1.27~1.48,P0.01）,miRNA-25（OR=1.14,95%CI： 1.09~1.22,P0.01） and CA19-9（OR=1.29,95%CI： 1.13~1.44,P0.01） had a significant correlation with prognosis.Prediction of miRNA-25 was detected by the ROC curve and area under the curve was 0.855（95%CI： 0.818~0.892,P0.01）.Conclusion miRNA-25 can be used as an independent diagnostic factor for gastric cancer,and the indicators should be included in gastric cancer diagnostic evaluation system,which can further increase the ability to assess risks and prognosis of the disease.