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两个新型4-羟基-3-喹啉羧酸酯类抗球虫化合物的合成

Synthesis of Two Novel 4-Hydroxy-3-Quinolinecarboxylates Anticoccidial Compounds
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摘要 经过亚硝化、催化加氢、缩合、醚化和关环等五步反应,设计并合成了两个新型4-羟基-3-喹啉羧酸酯类抗球虫化合物.新化合物的合成具有合成路线短、产率高、原料易得、易实现工业化等优点.所有化合物的结构均经1H NMR,IR和HRMS等方法确证. Two novel 4-hydroxy-3-quinolinecarboxylates anticoccidial compounds were designed and synthesized through five-step reactions of nitrification,catalytic hydrogenation,condensation,etherification and closed loop response.The new process is characterized by a short synthetic route,high yield and cheap raw material,which is convenient for the commercial production.The structures of these compounds are confirmed by 1H NMR,IR spectra and HRMS.
作者 严春蓉 李兰 吴凯群 王玉良
机构地区 四川大学化学学院 宜宾学院化学与化工学院
出处 《宜宾学院学报》 2012年第6期47-49,共3页 Journal of Yibin University
基金 国家自然科学基金项目(21072135) 宜宾学院博士科研启动基金项目(2010B09)
关键词 4-羟基-3-喹啉羧酸酯类抗球虫化合物 合成 亚硝化 催化加氢 缩合 醚化 关环 4-hydroxy-3-quinolinecarboxylates anticoccidial compounds synthesis nitrification catalytic hydrogenation condensation etherification closed loop response
分类号 G633.8 [文化科学—教育学]
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宜宾学院学报
2012年 第6期

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