心绞痛不同血瘀证型与Hs-CRP、IL-6、Lp-PLA_2的相关性

Correlation with Hs-CRP,IL-6 and Lp-PLA_2 in Angina Pectoris of Different Blood Stasis Patterns/Syndromes

目的探讨血瘀型心绞痛患者超敏c反应蛋白(Hs-CRP)、白介素6(IL-6)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平不同血瘀证分型的相关性。方法将150例心绞痛血瘀证患者辨证分为气虚血瘀组(36例)、痰浊血瘀组(45例)、血虚血瘀组(30例)、气滞血瘀组(18例)、热毒血瘀组(14例)、寒凝血瘀组(7例)。分别检测其Hs-CRP、IL-6、Lp-PLA2水平,进行统计学分析。结果Lp-PLA2水平:气虚血瘀组明显高于痰浊血瘀组、气滞血瘀组、热毒血瘀组、寒凝血瘀组(P<0.05);血虚血瘀组明显高于热毒血瘀组、寒凝血瘀组(P<0.05)。IL-6水平:痰浊血瘀组明显高于其他各组(P<0.05)。Hs-CRP水平:痰浊血瘀组明显高于气虚血瘀组、气滞血瘀组、热毒血瘀组、寒凝血瘀组(P<0.05);血虚血瘀组高于气虚血瘀组(P<0.05)。结论不同血瘀证型炎症因子水平有一定的变化规律,Hs-CRP、IL-6、Lp-PLA2水平可能成为血瘀证分型的客观依据。

Objective To explore the correlation with the levels of the high-sensitivity C-reactive protein（Hs-CRP）,interleukin-6（IL-6）and lipoprotein-associated phospholipase A2（Lp-PLA2）in the patients with angina pectoris of different blood stasis patterns/syndromes.Methods 150 cases of angina pectoris were differentiated as qi deficiency and blood stasis group（36 cases）,turbid phlegm and blood stasis group（45 cases）,blood deficiency and blood stasis group（30 cases）,qi stagnation and blood stasis group（18 cases）,heat toxin and blood stasis group（14 cases）and cold stagnation and blood stasis group（7 cases）.The levels of Hs-CRP,IL-6 and Lp-PLA2 were detected separately for statistical analysis.Results Concerning to Lp-PLA2 level,the result in qi deficiency and blood stasis group was higher apparently than that in turbid phlegm and blood stasis group,qi stagnation and blood stasis group,heat toxin and blood stasis group and cold stagnation and blood stasis group（P0.05）;the result in blood deficiency and blood stasis group was higher apparently than that in heat toxin and blood stasis group and cold stagnation and blood stasis group（P0.05）.Concerning to IL-6 level,the result in turbid phlegm and blood stasis group was higher apparently than the other groups（P0.05）.Concerning to Hs-CRP level：the result in turbid phlegm and blood stasis group was higher apparently than that in qi deficiency and blood stasis group,qi stagnation and blood stasis group,heat toxin and blood stasis group and cold stagnation and blood stasis group（P0.05）and the result in blood deficiency and blood stasis group was higher than that in qi deficiency and blood stasis group（P0.05）.Conclusion The different blood stasis patterns/syndromes bring a certain changing rule of the inflammatory factors.The levels of Hs-CRP,IL-6 and Lp-PLA2 are probably the objective evidences of the differentiation of blood stasis patterns/syndromes.