加减补中益气汤联合奥沙利铂、替吉奥方案治疗晚期胃癌随机对照临床研究

Clinical Observation of Buzhong Yiqi Decoction Combined with SOX Therapy on the Patient with Advanced Gastric Cancer

[目的]观察加减补中益气汤联合奥沙利铂、替吉奥(SOX)方案治疗晚期胃癌患者的临床疗效。[方法]采用随机、对照方法。将53例晚期胃癌患者随机分为两组,对照组26例采用SOX方案化疗,治疗组27例在对照组治疗的基础上同时口服加减补中益气汤,自化疗前3d开始服用,1剂/d,分2次温服,连续服用至化疗结束后3d。两组均以21d为1周期,完成2个周期后评价近期疗效、中医证候疗效、毒副反应等。[结果]两组近期疗效总有效率比较无明显差异(P>0.05)。在中医证候疗效、体力状况疗效方面,治疗组治疗后指标优于对照组(P<0.01);治疗组的白细胞减少、消化道反应、周围神经毒性程度优于对照组(P<0.05)。[结论]加减补中益气汤联合SOX方案治疗晚期胃癌可以改善患者的中医症候及体力状况,降低化疗毒副反应,优于单纯SOX方案化疗。

[Objective]Observing the impact of Buzhong Yiqi Decoction Combined with SOX（L-OHP、S1） therapy on the patient with Advanced Gastric Cancer.[Methods]53 cases with advanced gastric cancer randomly divied into two groups.26 cases of control were treated only with SOX program.On this basis,27 cases of treatment group were treated with SOX program plus Buzhong Yiqi decoction and took Buzhong Yiqi decoction 3 days before chemotherapy,one dose daily,twice a day,until 3 days after chemotherapy finished.Two groups regard 21days as a course of treatment.Observing the short term effect,clinical symptom,toxicity of the two groups after 2 cycles.[Results]On the short term effect,there is no significant difference between the two groups（P0.05）;On clinical symptom,physical condition,the index of treatment group after treatment was better than that of control group（P0.01）;neutropenia,gastrointestinal reactions and the toxicity of peripheral nerve of treatment group were lower than of control group（P0.05）.[Conclusion]Buzhong Yiqi decoction combined with SOX（L-OHP、S1） therapy can improve the clinical symptom and physical condition,alleviate the toxicity of chemotherapy.It is better than SOX therapy.