摘要
目的探讨吸烟对男性不育患者精子DNA完整性及精子形态的影响。方法 132例男性不育患者根据烟龄分为2组:A组烟龄1～5年;B组烟龄大于5年。正常对照组为100例非吸烟已生育健康男性。对其进行精子DNA完整性检测及精子形态学分析。结果 A组精子DNA碎片指数(DFI)和精子畸形率与正常对照组比较差异有显著性(P<0.05),而B组精子DNA碎片指数和精子畸形率与正常对照组比较差异有非常显著性(P<0.01)。结论长期吸烟可能会损伤男性精子DNA及影响精子形态,是引起男性不育的原因之一。
Objective： To investigate the effect of smoking on sperm DNA integrity and sperm morphology in male infertility patients.Methods： 132 cases of male infertility patients were divided into 2 groups： group A smoked 1 to 5 years;Group B smoked more than five years.Control group were 100 non-smoking male who already had their progenies.Analysis on sperm DNA integrity and sperm morphology were made.Results： DNA fragmentation index（DFI） and sperm deformity rate of group A were significantly higher than that of control group（P〈0.05）,and group B showed higher results（P〈0.01）.Conclusion： Long-term smoking may damage sperm DNA and affect sperm morphology,and thus is one of the causes of male infertility.
出处
《中国优生与遗传杂志》
2012年第10期118-118,67,共2页
Chinese Journal of Birth Health & Heredity
