妊娠期梅毒对新生儿的影响

Effect of gestational syphilis on the neonates

目的探讨妊娠合并梅毒对围生儿预后的影响。方法根据是否行抗梅毒治疗,将116例血清学检查确认为梅毒的孕妇分为全疗程治疗组(72例)和未治疗组(44例),比较两组孕妇的妊娠结局、围生儿预后及新生儿先天梅毒的发生情况。结果治疗组足月分娩率88.9%,而未治疗组仅为40.9%(P<0.01);治疗组早产及死胎的发生率分别为11.1%及0,明显低于未治疗组22.7%及36.4%(P<0.01);治疗组分娩的正常新生儿者占88.89%,而未治疗组仅占28.57%(P<0.01)。结论妊娠合并梅毒孕妇及早、规范治疗可以明显改善妊娠结局和围生儿预后,降低围生儿死亡率及先天梅毒的发生。

Objective To inrnestigate the effect of gestational syphilis on perinatal prognosis of neonates.Methods The 116 prengnant women with syphiliss were divided into treatment group（72 cases） and control group（44 cases）.The patients in treatment group were treated with a full course of anti-syphilis therapy and 44 cases in control group were taken as control,The pregnant outcome andperinatal porgosis were compared between two groups.Results The term delivery in treatment group was 88.9%,but it was 40.9% in the control group（P0.01）.The rates of premature birth and fetal intrauterine death was 11.1% and 0 in treatment group,much lower than 22.7% and 36.4% in the control group（P0.01）.The normal rate of neonates was 86.10% in treament group,significantly higher than that of 28.57% of the control group（P0.01）.Conclusion Early and regular treatment of gestational syphiliss can significantly improve the pregnant outcomes and perinatal prognosis.