十堰地区育龄妇女弓形虫血清流行病学分析

Serological investigation of toxoplasma infection in women of child-bearing age

目的探讨弓形虫感染对育龄妇女生殖健康的影响。方法采用金标免疫诊断试验和酶联免疫吸附试验测定1 316例育龄妇女血清弓形虫抗体IgG、IgM和循环抗原。结果1 316例育龄妇女中血清弓形虫抗体或循环抗原阳性171例,阳性率13.0%,阳性组中流产、死胎、畸形发生率高于阴性组(P<0.01);妇科疾病如子宫肌瘤、宫外孕、盆腔炎、不孕症的患病率也显著高于阴性组(P<0.01);饲养宠物者弓形虫阳性率高于不养宠物者(P<0.01)。结论育龄妇女弓形虫感染与异常妊娠结局及某些妇科疾病密切相关,加强对育龄妇女弓形虫血清学监测和健康教育具有十分重要的意义。

Objective To explore the impact of toxoplasma infection on the health of fertile women,s health.Methods The dot immunogold filtration（DIGFA） and ELISA were used to detect the IgG,IgM of toxoplasmosis antibody and circulation antigen（CAg） in sera from 1 316 women of child-bearing age.Results The total positive rate of IgG,IgM and CAg was 13.0%（171/ 1316）.The abortion rate,stillbirth rate and defect rate in positive group were significantly higher than in negative group（P0.01）.The morbidity of myoma of uterus,ectopic pregnancy,pelvic inflammation and infertility in positive group was significantly higher than in negative group（P0.01）.The positive rate of population of contacting with cat and dog frequently was significant higher than the population who do not（P 0.01）.Conclusion The abnormal pregnancy,some gynecopathy are closely related with toxoplasma infection in women of child-bearing age.Toxoplasmosis serological surveillance and health education be conducted among women of child-bearing age.