真菌多种耐药机制的研究进展

Progress in mechanism of multiple drug resistance of fungi

目前由于治疗全身真菌感染的药物有限和抗生素的滥用等因素致使真菌感染的发病率呈上升趋势。真菌的耐药现象日益增多.耐药真菌感染的治疗已成为一个非常棘手的临床问题。为了寻找控制耐药真菌的感染最佳策略线索,本文通过归纳目前临床常用和正在研发中的抗真菌药物耐药机制,对耐药机制进行深入的探讨,为临床用抗真菌治疗提供一定的理论依据。

At present,treatments for systemic fungal infection limited,and misuse of antibiotics lead to upward trends in the incidence of fungal infections in recent years,increasing resistance of fungi.Treatment of drug-resistant fungal infection has become a very difficult clinical problem.In search of drug-resistant fungal infection control best strategy lead,must explore mechanisms of drug resistance.This paper summarized the current clinical and is commonly used in the research and develop ment of antifungal resistance mechanisms,provides a reference for antifungal therapy for clinical use.