期刊文献+

WHOⅢ级胶质瘤患者放疗或联合化疗治疗的预后因素分析 被引量:11

Prognostic factors of WHO Ⅲ grade glioma patients treated with radiotherapy or chemotherapy
下载PDF
导出
摘要 目的:研究WHOⅢ级胶质瘤患者放疗或联合化疗治疗后的预后因素。方法:本组59例胶质瘤患者被纳入研究。所有患者手术后6个星期内开始总平均剂量为59.4 Gy的放疗,放疗之后4个星期内开始接受化疗。根据术后治疗方案分为单独放疗组和放疗加化疗组,所有患者治疗结束后均定期随访。生存质量采用Kaplan-Meyer法计算生存率并采用Log秩检验;多因素分析使用Cox比例风险模型。结果:总体生存期延长受年龄、良好体力状态、间变性少突胶质细胞瘤的组织学诊断、完全切除或放疗后加辅助PCV化疗独立影响。基于终末节点的中位生存期,可将研究对象分为4组。不依赖于组织学诊断,完全切除术后给予放疗加PCV化疗治疗的患者或不完全切除但具有最佳体力状态(ECOG评分0级)的患者可预期达到更长的生存期。基于术后临床环境,使用目前的结果可估算生存概率。结论:分组可以成功预测WHOⅢ级胶质瘤患者的生存期。体力状态、切除范围、组织学诊断和治疗方式是患者生存期的主要决定因素。 Objective:To study the prognostic factors of WHO Ⅲ grade glioma patients treated with radiotherapy or chemotherapy.Methods:Totally 59 gliomas patients were included in this study.All patients within six weeks after the operation began radiotherapy with total average dose of 59.4 Gy and received chemotherapy at four weeks after radiotherapy.They were divided into radiotherapy(RT)group and combined radiochemotherapy(RCT)group according to their treatment methods after the operation.All patients were followed up periodically after treatment.Survival probabilities were estimated based on Kaplan-Meyer survival analysis and Log rank test.Cox proportional-hazards model was used for multivariate regression analysis.Results:The prolonged overall survival time was affected by age,good physical condition,anaplastic oligodentrocytoma histological diagnosis,complete resection or radiotherapy plus PCV chemotherapy.Based on the median survival time of the terminal node,all patients in this study were divided into four groups.Patients received radiotherapy plus PCV chemotherapy after complete resection without depending on histological diagnosis and those with incomplete resection but the best physical condition(ECOG score was 0 grade)can be expected to achieve a longer lifetime.Based on the postoperative clinical environment,the current results can be used to estimate the probability of survival.Conclusions:The grouping can successfully predict the survival time of patients with WHO Ⅲ grade glioma.Physical condition,extent of resection,histological diagnosis and treatment methods are the major determinants for the survival time of patients.
作者 罗飞
出处 《重庆医科大学学报》 CAS CSCD 北大核心 2012年第11期976-979,共4页 Journal of Chongqing Medical University
关键词 胶质瘤 放疗 化疗 预后因素 glioma; radiotherapy; chemotherapy; prognostic factors
  • 相关文献

参考文献7

二级参考文献59

共引文献54

同被引文献92

  • 1周际昌.实用肿瘤内科学[M].第2版.北京:人民卫生出版社,2005.386-388.
  • 2江涛,马文兵,杨学军.脑胶质瘤治疗技术与进展[M].北京:人民卫生出版社,2011.
  • 3Prabhu RS,Won M,Shaw EG,et al. Effect of the addition of chemo therapy to radiotherapy on cognitive function in patients with low- grade glioma.-Secondary analysis of RTOG 98-02[J]. J Clin Oncoh 2014,32(6) :535-541.
  • 4Liang C, Guo S, Yang L. Effects of all-trans retinoic acid on VEGF and I-IIF-la expression in glioma cells under normoxia and hypoxia and its anti-angiogenic effect in an intracerebral glioma model [J]. Mol Med Rep, 2014, 10(5): 2713-2719. doi: lO,3892/mmr.2014.2543.
  • 5Kim J, Lee JS, Jung J, et al. Emodin suppresses mainte- nance of sternness by augmenting proteosomal degradation of epidermal growth factor receptor/epidermal growth factor receptor variant III in glioma stem cells [J]. Stem Cells Dev, 2015, 24(3): 284-295. doi: 10.1089/seal.2014.0210.
  • 6Yu B, Ruan M, Dong X, et al. The mechanism of the opening of the blood-brain barrier by borneo/: a pharmacodynamics and pharmacokinetics combination study [J]. J Ethnophar- macol, 2013, 150(3): 1096-1108.
  • 7McCarthy RC, Kosman DJ. Activation of C6 glioblastoma cell ceruloplasmin expression by neighboring human brain endothelia-derived interleukins in an in vitro blood/,brain barrier model system[J]. Cell Commun Signal, 2014, 12(1): 65.
  • 8Yu B, Ruan M, Dong X, et al. The mechanism of the opening of the blood-brain barrier by borneol: A pharmaeodynamics and pharmaeokinetics combination study [J]. J Ethnophar- macol, 2013, pii: $0378-8741(13)00735-6. doi: 10.1016/ j.jep.2013.10.028.
  • 9Li XT, Ju R J, Li XY, et al. Multifimetional targeting dan- nornbiein plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells [J].Oncotarget, 2014, 5(15): 6497-511.
  • 10Yao H, Wang K, Wang Y,et al, Enhanced blood-brain bar- rier penetration and glioma therapy mediated by a new pep- tide modified gene delivery system [J].Biomaterials, 2015, doi: 10.1016/j.biomaterials.2014.10.034.

引证文献11

二级引证文献39

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部