强迫症患者反应控制能力研究

Research on response control ability of patients with obsessive compulsive disorder

目的:探讨强迫症(Obsessive-compulsive disorder,OCD)患者反应控制障碍。方法:运用停止信号任务,比较21例OCD患者与23例年龄匹配健康者的停止信号反应时(Stop signal reaction time,SSRT)和非停止信号反应时(No-signal reactiontime,NSRT)等。结果:患者的SSRT和NSRT[(376.20±71.92)ms;(804.33±107.82)ms]均分别较健康对照[(304.13±76.73)ms;(714.98±97.01)ms]显著延长:t=3.206,P=0.003;t=2.894,P=0.006。运用协方差分析去除NSRT影响,两组间SSRT差异仍显著:F=22.518,P=0.000。分别对两组SSRT与停止信号任务的其余指标以及Y-BOCS分数进行了逐步线性回归分析。结论:OCD病人反应抑制和反应执行能力均明显下降。

Objective：To evaluate the response control function of patients suffering from obsessive compulsive disorder（OCD）.Methods：Twenty-one OCD patients and 23 healthy controls were enrolled.All patients and healthy controls performed the stopsignal task which provides the indications reflecting the ability of response inhibition：stop signal reaction time（SSRT）and no-signal reaction time（NSRT）.The results of the two groups were analyzed and compared.Results：Both SSRT（376.20±71.92）ms and NSRT（804.33±07.82）ms of OCD group were significantly longer than those of control group（304.13±76.73）ms,（714.98±97.01）ms：t=3.206,P=0.003;t=2.894,P=0.006.After the removal of the influence of NSRT by covariance analysis,the significant difference of SSRT between the two group was still found：F =22.518,P = 0.000.The stepwise multiple regression analysis was carried out for SSRT and the other indexes of the task and Y-BOCS score.Conclusion：The ability of both response inhibition and response executive of OCD patients was significantly decreased.