慢性胰腺炎疼痛机制研究进展

Pain mechanism in chronic pancreatitis: an update

慢性胰腺炎导致的顽固性胰腺疼痛往往很难利用现有临床疗法有效解决。人们对这种疼痛的机制尚不清楚,虽然导管和实质压力增加是引起胰腺炎疼痛的主要原因,但充足的证据表明神经病理性疼痛也是很重要的原因之一。此外,最近的研究证实脊髓以上和较高的大脑中枢在胰腺炎疼痛维持中起到重要作用。本文重点阐述了对慢性胰腺炎疼痛产生和维持起作用的外周及中枢发病机制。

Pancreatic pain caused by chronic pancreatitis is often difficult to cure by current therapy.Such pain mechanism still remains unclear.Although the increase of pressure on the duct and solid tissue is the main cause of pancreatitis pain,enough evidence has showed that the neuropathic pain is a very important reason.In addition,recent studies have confirmed that the center of spinal cord above and higher centers in the brain play important roles in the maintenance of pancreatitis pain.This review focuses on the peripheral and central pathogeneses in the development and maintenance of chronic pancreatitis pain.