纳米磷酸钙人工骨应用于经皮椎体后凸成形术的短期临床观察

Application of nanometer calcium phosphate ceramic artificial bone in percutaneous kyphoplasty: a short-term clinical observation

目的观察纳米磷酸钙人工骨应用于经皮椎体后凸成形术治疗骨质疏松性椎体压缩性骨折的临床效果。方法选择33例骨质疏松性胸腰椎压缩性骨折患者,均在全身麻醉下行纳米磷酸钙人工骨单球囊双侧扩张经皮椎体后凸成形术。计算手术后椎体前缘复位率和后凸矫正率,记录术前及术后的疼痛评分,观察术前、人工骨注入时、注入后5min及术毕的血压、血氧饱和度(SPO2)变化。结果椎体复位率及后凸矫正率分别为(24.90±3.02)%和(45.80±7.13)%,术后疼痛明显减轻。人工骨注入后血压均较平稳,SPO2在各时点差异无统计学意义(P>0.05)。结论纳米磷酸钙人工骨应用于经皮椎体后凸成形术治疗骨质疏松性椎体压缩性骨折安全有效,对患者的生命体征影响较小。

Objective To observe the clinical effects of nanometer calcium phosphate ceramic artificial bone（NCPCAB） in percutaneous kyphoplasty for treatment of osteoporotic vertebral compression fractures. Methods Totally 33 cases of osteoporotic vertebral compression fractures were selected in the present study.All cases were injected with NCPCAB for percutaneous kyphoplasty via bilateral transpedicular balloon approach.Anterior vertebral reset rate and kyphosis correction rate were calculated after treatment.The visual analogue scales（VAS） were observed preoperatively and postoperatively.The changes of blood pressure and SPO2 were observed preoperatively,at injection of the artificial bone,5 min after injection and at the end of surgery. Results The postoperative vertebra reduction rate and kyphosis correction rate were（24.90±3.02）% and（45.80±7.13）%,respectively.The pain was greatly reduced after operation.The blood pressure was stable after injection of the artificial bone,and SPO2 was not markedly different at each time point. Conclusion Application of NCPCAB in percutaneous kyphoplasty is safe and effective for treatment of osteoporotic vertebral compression fractures,with little influence on the vital signs of patients.