摘要
目的:探讨广西壮族人群的HLA-A、B、DRB1基因多态性与神经纤维瘤病Ⅰ型的相关性。方法:选取25例广西壮族神经纤维瘤病Ⅰ型患者作为病例组,98例壮族健康个体为对照组,应用直接测序法(sequence-based typing,SBT)比较两组HLA-A、B、DRB1基因多态性有无差异。结果:病例组的A*2601、B*1518、DRB1*0406、DRB1*1032的频率显著高于对照组(P<0.05)。结论:广西壮族神经纤维瘤病Ⅰ型患者HLA-A、B、DRB1的等位基因频率均与广西壮族正常人群不同。
Objective：To identify the Relationship of HLA-A,B,DRB1 Alleles Polymorphism in Guangxi Zhuang population and neurofibromatosis type Ⅰ.Methods：25 neurofibromatosis type Ⅰ patients of Guangxi Zhuang population and 98 healthy cases were taken blood and extracting genomic DNA.The target gene fragments were amplifying by sequence-based typing.Results：A＊2601,B＊1518,DRB1＊0406,DRB1＊1032 genotype frequencies between the study group and the healthy control group were significantly different（P0.05）.Conclusion：The A＊2601,B＊1518,DRB1＊0406,DRB1＊1032 allele frequencies in the neurofibromatosis type I patients of Guangxi Zhuang population were were lower than the heathy.
出处
《医学理论与实践》
2012年第20期2463-2464,共2页
The Journal of Medical Theory and Practice
基金
广西壮族自治区卫生厅科研项目
项目编号:Z2009402
