氟伐他汀对慢性心力衰竭患者循环血中细胞因子和心功能的干预作用

Fluvastatin in Patiens with Chronic Heart Failure on the Cycle of Blood Cell Factor and Cardiac Function in the Role of Intervention

目的:观察氟伐他汀对慢性心力衰竭患者血浆中细胞因子(肿瘤坏死因子-α、高敏C反应蛋白)水平的影响及心功能的干预作用。方法:将102例患者随机分为对照组(常规治疗)和干预组(在常规治疗的基础上加用氟伐他汀),共6个月。两组治疗前及治疗后1个月、3个月、6个月分别检查心脏超声,评估心功能,测定肿瘤坏死因子-α(TNF-α)、高敏C反应蛋白(hs-CRP)和血脂水平。结果:心功能Ⅳ级患者血浆TNF-α、hs-CRP水平较Ⅱ级明显增高(P<0.01)。两组治疗后血浆TNF-α、hs-CRP水平较治疗前均明显降低(P<0.01),但干预组下降更明显。两组治疗后心功能均得到明显改善。结论:氟伐他汀能降低血浆细胞因子(TNF-α、hs-CRP)水平,改善心功能,有益于慢性心力衰竭的治疗。

Objective：To observe the effect of fluvastatin in patients with chronic heart failure on the plasma cytokines（tumor necrosis factor-α,hypersensitive C-reactive protein） levels in heart function and role of the intervention.Methods：One hundred and two cases were randomly divided into control group（conventional treatment） and the intervention group（in the conventional treatment on the basis of the increase with fluvastatin）,a total of six months.The two groups before and after treatment a month,three months,six months,respectively heart ultrasound examination to assess cardiac function,the determination of tumor necrosis factor-α（TNF-α）,hypersensitive C reactive protein（hs-CRP） and Lipid levels.Results：The results of cardiac function in patients with grade Ⅳ TNF-α,hs-CRP level was significantly higher than the level Ⅱ（P0.05）.The two groups after treatment of plasma TNF-α,hs-CRP levels than before treatment were significantly lower（P0.05）,but the intervention group also decreased significantly（P0.01）.Two sets of cardiac function after treatment were significantly improved.Conclusion：Fluvastatin reduces plasma cytokines（TNF-α,hs-CRP） levels and improve heart function,the benefit of the treatment of chronic heart failure.