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双相障碍抑郁发作患者治疗前后血清脑源性神经营养因子水平变化及相关因素分析 被引量：11

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摘要 目的探讨双相障碍抑郁发作患者血清脑源性神经营养因子(BDNF)水平与发作和疗效的关系。方法采用病例-对照及前瞻性自身对照设计。对双相障碍抑郁发作组患者(n=30)给予治疗[包括情绪稳定剂、非典型抗精神病药、抗抑郁药及改良电抽搐治疗(MECT)],并随访治疗4周;采用酶联免疫吸附法(ELISA)测定双相障碍抑郁发作组患者治疗前和治疗第4周末及江西省精神病院职工(对照组)(n=30)的血清BDNF水平,并对双相障碍抑郁发作组患者于治疗前及治疗第4周末采用汉密尔顿抑郁量表(HAMD)评定症状程度。结果双相障碍抑郁发作组治疗前血清BDNF水平[(18.65±6.13)ng/mL]显著低于对照组[(24.87±6.08)ng/mL](t=3.941,P=0.000),并与治疗前HAMD总分呈负相关(r=-0.413,P=0.023);治疗第4周末血清BDNF水平[(22.56±6.56)ng/mL]显著高于治疗前(t=-4.089,P=0.000),与对照组的差异均无统计学意义(P>0.05),并与治疗后HAMD总分呈负相关(r=-0.619,P=0.000);治疗4周末血清BDNF增加率与HAMD减分率呈正相关(r=0.372,P=0.043)。结论血清BDNF水平低下与双相障碍抑郁发作密切相关,可能是双相障碍抑郁发作的状态指标;血清BDNF水平升高可能为双相障碍抑郁发作临床疗效的参考指标之一。
作者 金海淼 胡斌 张咏梅 陈美英 魏丹 夏贤卿 龚发金
机构地区 江西省精神病院精神科
出处 《广东医学》 CAS CSCD 北大核心 2012年第19期2949-2951,共3页 Guangdong Medical Journal
关键词 双相障碍 抑郁发作 脑源性神经营养因子 血清
分类号 R749.4 [医药卫生—神经病学与精神病学]
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参考文献17

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共引文献5

同被引文献61

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引证文献11

二级引证文献67

广东医学
2012年 第19期

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