期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

神经病理性痛外周自发放电与钙激活钾离子通道的研究进展 被引量：2

下载PDF
导出
摘要 神经病理性痛是一类特殊疼痛,其直接来源于影响躯体感觉系统的损伤或疾病,以自发性疼痛、痛觉过敏和痛觉超敏为特征[1]。正常神经纤维只传递信号,有研究[2]发现,大鼠外周神经损伤区域可以产生自发放电,这种异位放电发生于有髓传入神经纤维,以A类纤维为主。深入研究发现,在外周神经系统（peripheral nervous system）中有离子通道参与到不同性质疼痛的产生与维持中，
作者 李建宁 刘一辉 任维
机构地区 陕西师范大学生命科学学院 宁夏医科大学基础医学院生物化学与分子生物学系
出处 《广东医学》 CAS CSCD 北大核心 2012年第19期3013-3015,共3页 Guangdong Medical Journal
基金 国家自然科学基金资助项目(编号:30900443)
关键词 神经病理性痛 钾离子通道 自发放电 钙激活 传入神经纤维 自发性疼痛 神经损伤区 外周神经系统
分类号 R741.041 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献22

  • 1VINIK A. The approach to the management of the patient with neuropathic pain[J]. J Clin Endocrinol Metab, 2010, 95( 11 ) : 4802 - 4811.
  • 2CHEN Y, DEVOR M. Ectnpic mechanosensitivity in injured sensory axons arises from the site of spontaneous electrogenesis [J]. Eur J Pain, 1998, 2(2) : 165 -178.
  • 3万有.神经病理痛的外周机制[C].中华医学会疼痛学分会第七届年会论文摘要集,2007.
  • 4刘蔡钺,赵云富,马蓓.大电导钙依赖的钾通道(BKca通道)与疼痛[J].生命的化学,2010,30(3):449-453. 被引量：3
  • 5SCHOLZ A, GRUSS M, VOGEL W. Properties and functions of calcium - activated K^+ channels in small neurones of rat dorsal root ganglion studied in a thin slice preparation[J]. J Physiol, 1998, 513(Pt 1): 55-69.
  • 6ZHANG X L, MOK L P, KATZ E J, et al. BKCa currents are enriched in a subpopulatiort of adult rat cutaneous nociceptive dorsal root ganglion neurons [ J ]. Eur J Neurosci, 2010, 31 (3) : 450 - 462.
  • 7GHATTA S, NIMMAGADDA D, XU X, et al. Large -conductance, calcium -activated potassium channels: structural and functional implications[ J ]. Pharmacol Ther, 2006, 110( 1 ) : 103 -116.
  • 8LEE U S, CUI J M. BK channel activation: structural and functional insights[J]. Trends Neurosci, 2010, 33(9) : 415 -423.
  • 9MONGAN L C, HILL M J, CHEN M X, et al. The distribution of small and intermediate conductance calcium - activated potassium channels in the rat sensory nervous system [ J ]. Neuroscience, 2005, 131(1): 161-175.
  • 10KOHLER M, HIRSCHBERG B, BOND C T, et al. Small - conductance, calcium - activated potassium channels from mammalian brain[J]. Science, 1996, 273(5282): 1709-1714.

二级参考文献25

  • 1朱仲玲,王芳,吴周环,龙利红,金悠,陈建国.培养的大鼠三叉神经节细胞钙激活钾通道的氧化性调节[J].中国应用生理学杂志,2006,22(4):390-393. 被引量：2
  • 2马彬云,汲娟娟.BK_(Ca)通道的结构与功能[J].生物物理学报,2007,23(1):11-19. 被引量：14
  • 3Lee Y-J et al. Painful channels in sensory neurons. Mol Cell, 2005, 20:315-324.
  • 4Ghatta Set al. Large conductance, calcium-activated potassium channels: structural and functional implications. Pharmacol Ther, 2006, 110:103-116.
  • 5Atkinson NS et al. A component of calcium-activated potassium channels encoded by the Drosophila locus. Science, 1991, 253:551-565.
  • 6Ocana Met al. Potassium channels and pain: present realities and future opportunities. Eur J Pharmacol, 2004, 500: 203- 219.
  • 7Biagi G et al. Synthesis and biological activity of novel substituted benzanilides as potassium channel activators. Eur J Med Chem, 2004, 39:491-498.
  • 8Olesen SP et al. Selective activation of Ca2+-dependent K+ channels by novel benzimidazolone. Eur J Pharmacol, 2004, 251:53-59.
  • 9McManus OB et al. An activator of calcium-dependent potassium channels isolated from a medicinal herb. Biochemistry, 1993, 32:6128-6133.
  • 10Roberto RA et al. Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-α receptor agonist GW7647. Eur J Pharmacol, 2007, 566:117-119.

共引文献2

同被引文献30

  • 1寿雯婷,张世红,陈忠.钠离子通道在神经病理性疼痛中的作用研究进展[J].浙江大学学报（医学版）,2011,40(2):217-221. 被引量：11
  • 2Jun Zhong,Shi-Ting Li,Jin Zhu,Hong-Xin Guan,Qiu-Meng Zhou,Wei Jiao,Ting-Ting Ying,Xiao-Sheng Yang,Wen-Chuang Zhan,Xu-Ming Hua.A clinical analysis on microvascular decompression surgery in a series of 3000 cases[J].Clinical Neurology and Neurosurgery.2012(7)
  • 3Jin Zhu,Shi-Ting Li,Jun Zhong,Hong-Xin Guan,Ting-Ting Ying,Min Yang,Xiaosheng Yang,Qiumeng Zhou,Wei Jiao.Role of arterioles in management of microvascular decompression in patients with hemifacial spasm[J].Journal of Clinical Neuroscience.2011(3)
  • 4Jun Zhong.An ideal microvascular decompression technique should be simple and safe[J].Neurosurgical Review.2012(1)
  • 5Min Liu,John N. Wood.The Roles of Sodium Channels in Nociception: Implications for Mechanisms of Neuropathic Pain[J].Pain Medicine.2011
  • 6Anna M.W. Taylor,Alfredo Ribeiro-da-Silva.GDNF levels in the lower lip skin in a rat model of trigeminal neuropathic pain: Implications for nonpeptidergic fiber reinnervation and parasympathetic sprouting[J].Pain.2011(7)
  • 7Qiang Wang,Jie Cao,Qin Zhu,Chunye Luan,Xiaodong Chen,Xiaohua Yi,Haixia Ding,Jian Chen,Jie Cheng,Hang Xiao.Inhibition of voltage-gated sodium channels by bisphenol A in mouse dorsal root ganglion neurons[J].Brain Research.2011
  • 8Jun Zhong,Jin Zhu,Shi-Ting Li,Hong-Xin Guan.Microvascular Decompressions in Patients With Coexistent Hemifacial Spasm and Trigeminal Neuralgia[J].Neurosurgery.2011(4)
  • 9SoonwookChoi,EunahYu,DaesooKim,Francisco J.Urbano,VladimirMakarenko,Hee‐SupShin,Rodolfo R.Llinás.Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q‐ and T‐type calcium channels: a study in mutant mice[J].The Journal of Physiology.2010(16)
  • 10Asami Mori,Tomoyo Miwa,Kenji Sakamoto,Tsutomu Nakahara,Kunio Ishii.Pharmacological evidence for the presence of functional β3-adrenoceptors in rat retinal blood vessels[J].Naunyn - Schmiedeberg’s Archives of Pharmacology.2010(2)

引证文献2

二级引证文献3

广东医学
2012年 第19期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部