凝血指标与肺癌患者病情相关性研究

Correlation Between Indexes of Blood Coagulation and Level of Severity in Lung Cancer

目的探讨肺癌患者初发、缓解、复发时各凝血指标的相关性。方法对照组30名和经病理或细胞学证实的100例肺癌患者,根据临床病例分析分为初发组、复发组和缓解组。对各组凝血指标,包括凝血酶原时间(PT)、部分凝血活酶时间(APTT)、纤维蛋白原时间(FIB)、D-二聚体、抗凝血酶Ⅲ(AT-Ⅲ)进行测定,比较各组间有无差异,并分析它们与肺癌病情变化的关系。结果肺癌患者初发组和复发组血浆D-二聚体、FIB水平高于缓解组和对照组,AT-Ⅲ水平低于缓解组和对照组,差异有统计学意义(P<0.05)。PT、APTT差异无统计学意义(P>0.05)。肺癌患者D-二聚体、FIB水平高于对照组,AT-Ⅲ水平低于对照组,差异有统计学意义(P<0.05),肺癌Ⅰ～Ⅱ期与Ⅲ～Ⅳ期比较以上三指标差异有统计学意义(P<0.05)。结论常规凝血指标可以作为肺癌的诊断、治疗监测和预后指标,评估病情发展趋向。

Objective To explore the correlation between the blood coagulation and the level of severity patients with lung cancer.Methods 100 patients with lung cancer confirmed by pathological or cytology were divided into incipient group,recurrence group and remission group.The blood coagulation index including prothrombin time（PT）,part blood coagulation time（APTT） live enzyme,fibrinogen time（FIB）,d-dimer and anticoagulant enzyme Ⅲ（AT-Ⅲ） in patients and 30 health controls were detected.Results The plasma levels of d-dimer and FIB in incipient group and recurrence group patients were higher,and AT Ⅲ level were lower than that of remission group and controls（P0.05）.There were no significant difference in PT and APTT between them（P0.05）.The levels of d-dimer and FIB in patients with lung cancer were higher and AT-Ⅲ levels were lower than those of control group（P0.05）.There were significant difference in levels of d-dimer,FIB and AT-Ⅲ levels between the patients with lung cancer in I-II stages and III-IV stages（P0.05）.Conclusion The routine blood coagulation index could be used as an index in diagnosis,treatment and evaluation of prognosis of lung cancer.