糖化血红蛋白与空腹血糖在2型糖尿病诊断中价值的比较

The Value of Glycated haemoglobin A1c for the diagnosis of type 2 diabetes compared with fasting plasma glucose

目的:评估糖化血红蛋白(HbA1c)在诊断2型糖尿病(T2DM)中的价值。方法:251名患者行口服葡萄糖耐量试验(OGTT),同时测定HbA1c,绘制受试者工作特征(ROC)曲线。结果:HbA1c诊断T2DM的最佳界值为7.05%,此时灵敏度为91.1%,特异度为92.8%,曲线下面积(AUC)为0.971;空腹血糖(FPG)诊断T2DM的最佳界值为6.94mmol/L,此时灵敏度为81%,特异度为100%,AUC为0.944。结论:以HbA1c≥7.05%为DM诊断标准,敏感性较FPG(界值为6.94)高,特异性较FPG低。

Objective： To evaluate the role of HbA1c in T2DM diagnosis.Methods：251 patients were underwent oral glucose tolerance test（OGTT） and HbA1c measurement.The receiver operating characteristic（ROC） curve was drawing.Results：The optimal cut-point of ROC curve of HbA1c is 7.05%,with sensitivity of 91.1%,specificity of 92.8%,area under the curve（AUC） of 0.971.However,the optimal cut-point of ROC curve of FPG was 6.94mmol/L,with sensitivity of 81%,specificity of 100%,area under the curve（AUC） of 0.944.Conclusion：Compared with FPG（cut-point： 6.94 mmol/L）,HbA1c（cut-point： 7.05%） has higher sensitivity but lower specificity.