复方α-酮酸治疗维持性血液透析患者低蛋白血症的临床观察

Clinical observation studies Compound recipe a-keto acid to treatment the nutritional status treatment in maintenance hemodialysis patients with lower albuminemia

目的:研究复方α-酮酸(科罗迪)对改善维持性血液透析患者营养状况的有效性,观察对维持性血液透析患者相关营养指标血清白蛋白(ALB)、胆固醇(TC)、甘油三酯(TG)的影响。方法:选择40例低蛋白血症的血液透析患者,治疗组20例服用复方α-酮酸片和对照组20例未服用。分别在实验开始及6个月后检测患者血肌酐、尿素氮、血清白蛋白、总胆固醇、甘油三酯浓度。结果:经6个月治疗后,治疗组血白蛋白较前明显升高(P<0.01),总胆固醇和甘油三酯明显下降(P<0.01);对照组血白蛋白及血脂无明显变化。结论:复方α-酮酸(科罗迪)可有效改善维持性血液透析患者的营养状况。

Objective： To study the effectiveness of alpha keto acid compound（Keluo Di）to the nutritional status and nutritional indicators serum albumin（ALB）,cholesterol（TC）,triglyceride（TG）in maintenance hemodialysis patients.Methods：Select 40 cases of hypoalbuminemia in hemodialysis patients,20 cases as treatment group taking the alpha keto acid compound tablets and 20 cases as control group not taking.Serum creatinine,blood urea nitrogen,serum albumin,total cholesterol,triglyceride concentrations were detected at the start of test and 6 months later.Results：After 6 months treatment,the concentration of serum albumin were increased significantly（P0.01）and the levels of total cholesterol and triglycerides were decreased significantly（P0.01） in treatment group;but there were no obvious changes in control group.Conclusion：Alpha keto acid compound（Keluo Di）can effectively improve the nutritional status in maintenance hemodialysis patients.