期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

TLR4基因多态性与疾病易感性的研究进展 被引量：2

Advancement of the Relationship between Gene Polymorphisms of Toll-Like4 Receptors and Diseases
下载PDF
导出
摘要 Toll样受体是近年来发现的跨膜信号传递受体,作为一种重要的模式识别受体(PRRs)在多种疾病中起着重要的作用。基因多态性影响机体对疾病的遗传易感性。TLR4作为跨膜受体与多种疾病有着密切的联系,越来越多数据表明,TLRs单核苷酸多态性(SNPs)与多种疾病遗传易感性相关,本文就TLR4 SNPs与多种疾病的遗传易感性之间相关性进行综述。 Objective： Toll like receptors（TLRs） were identified as transmembrane signal transduction proteins in recent years,and single nucleotide polymorphisms of TLR genes are associated with the inflammatory responses and susceptibility to many diseases.Most studies have indicated that single nucleotide polymorphisms of TLR4 has close correlations with the pathogenesis of many diseases.In this review,we summarized the relationship between genetic polymorphisms of TLR4 and several disease.
作者 刘晓聪 沈关心 朱慧芬 陈琰琰 姜素华
机构地区 石河子大学医学院病原生物学与免疫学教研室 华中科技大学同济医学院免疫系
出处 《农垦医学》 2012年第3期258-262,共5页 Journal of Nongken Medicine
关键词 TLR4 单核苷酸多态性 疾病 TLR4 SNPs disease
分类号 Q75 [生物学—分子生物学]
  • 相关文献

参考文献26

  • 1Medzhitov R, Preston-Hudbun P,Janeway CA Jr. A human homo- logue of the Drosophila Toll protein signal activation of adaptive immunity[ J ]. Nature, 1997,388 (6640) :394 - 397.
  • 2Song PI, Abraham TA, Park Y ,et al. The expression of functional LPS receptor proteins CD14 and Toll-like receptor 4 in human cor- ned cells[ J]. Invest Ophthalmol Vis Sci ,2001,42 ( 12 ) :2867 - 2877.
  • 3Backhed F, Homef M. Toll-like receptor 4-mediated signalling by epithelial surfaces : necessity or threat [ J ]. Microb Infect, 2003,5 (11) :951 -959.
  • 4Abreu MT,Amold ET,Thomas LS,et al. TLR4 and MD-2 cxpres- sion is regulated by immune mediated signals in intestinal epitheli- al cells [J]. J Biol Chem,2002,277 : 26431 -26437.
  • 5Palsson-McDermott EM, O'Neill LAJ. Signal transduction by the li- popolysaccharide, Toll-like receptor [ J ]. Immunology, 2004, 113 (2) :153 -162.
  • 6Akira S,Takeda K. Toll-like receptor 8igaaling[ J]. Nat Re Im- munol,2004 4(7) : 499 -511.
  • 7林李淼,陈浩,闵小彦,夏宣平,王文星,张定亮,郑波,林秀清.浙江汉族人群Toll样受体4基因多态性与幽门螺杆菌相关消化性溃疡的关系[J].胃肠病学,2008,13(6):368-371. 被引量：3
  • 8薛惠平,倪培华,吴洁敏,童菊芳.炎症性肠病Toll样受体的基因多态性及其在不同人群中的分布[J].上海交通大学学报（医学版）,2007,27(10):1226-1231. 被引量：3
  • 9E1-Omar EM, Ng MT, Hold GL, Polymorphisms in Toll-like recep- tor genes and risk of cancer [ J ]. Oncogene, 2008,27 ( 2 ) : 244 - 252.
  • 10Hishida A, Matsuo K, Goto Y, et al. Toll-like receptor 4 + 3725 G/C polymorphism, 1-Ielieobaeter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese [ J]. Helicobact- er,2009,14( 1 ) :47 - 53.

二级参考文献42

共引文献11

同被引文献41

  • 1喻镁佳,李惠民.抗血管生成治疗淋巴瘤研究进展[J].实用肿瘤学杂志,2005,19(1):69-72. 被引量：3
  • 2Pau| A, William T, Andrew W, et al. De Novo treatment of diffuse large B - cell lymphoma with rituximab, cyclophos- phamide, vincristine, gemcitabine, and prednisolone in pa- tients with cardiac comorbidity:a United Kingdom NationalCancer Research Institute Trial [ J 1. Journal of Clinical On- cology,2014,32(4) :282 - 288.
  • 3Yunusova T, Akhtar M, Pohoratsky V. Analysis of LPS - in- duced, NF - KB - dependent interleukin - 8 transcription in kidney embryonic cell line expressing TLR4 using luciferase assay [ J ]. Methods Mol Biol,2014,11 ( 72 ) :305 - 314.
  • 4Huang Z, Yang Y, Jiang Y, et al. Anti - tumor immune re- sponses of tumor associated macrophages via toll - like re- ceptor 4 triggered by cationic polymers [ J ]. Biomaterials, 2013,34(3) :746 -755.
  • 5Peng SL. Signaling in B cells via Toll - like receptors [ J ]. Curr Opin Immunol,2005,17 (3) : 230 - 236.
  • 6Ibrahim ZA, Armour CL, Phipps S, et al. RAGE and TLRs. relatives ,friends or neighbours [ J ]. Mol Immunol, 2013,56 (4) :739 -744.
  • 7Diebold SS, Massacrier C, Akira S, et al. Nucleic acid ago- nists for Toll - like receptor 7 are defined by the presence of uridine ribonucleotides [ J ]. Eur J Immunol, 2006,36 ( 12 ) : 3256 - 3267.
  • 8Song DH, Lee JO. Sensing of microbial molecular patterns by Toll - like receptors [ J ]. Immunol Rev, 2012,250 ( 1 ) : 216 -229.
  • 9Pal D, Dasgupta S, Kundu R, et al. Fetuin - A acts as an endogenous ligand of TLR4 to promote lipid - induced in- sulin resistance [ J ]. Nat Med,2012,18 ( 8 ) : 1279 - 1285.
  • 10Arribillaga L, Durautez M, Lozano T, et al. A fusion protein between streptavidin and the endogenous TLR4 ligand EDA targets biotinylated antigens to dendritic cells and induces T cell responses in vivo[J]. Biomed Res lnt,2013,8(3 ) : 864720 - 864731.

引证文献2

农垦医学
2012年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部