摘要
目的探讨早期应用杏灵分散片治疗对急性冠状动脉综合征患者血清TNF-α,IL-6及hs-CRP表达及心功能的作用。方法纳入经冠状动脉造影证实的急性冠状动脉综合征患者126例,用随机数字表简单随机化方法分为常规治疗组和杏灵分散片组,常规治疗组口服阿司匹林、β受体阻断剂、单硝酸异山梨醇酯、氯吡咯雷、阿托伐他汀等治疗,杏灵分散片组在常规治疗的基础上给予杏灵分散片1片,每日3次。所有患者行超声心动检查,测定左心室射血分数(LVEF),评价心功能。观察治疗前和治疗后12周,患者血清TNF-α、IL-6、hs-CRP水平和LVEF的变化,结果治疗前两组TNF-α、IL-6、hs-CRP、LVEF水平比较差异无统计学意义。与治疗前相比,杏灵分散片组患者治疗12周后,血清TNF-α[(10.36±3.56)ng/L比(16.21±4.87)ng/L]、IL-6[(70.38±18.23)ng/L比(189.23±95.39)ng/L]及hs-CRP[(1.75±0.86)mg/L比(7.21±3.02)mg/L]的水平都有了进一步的降低(均为P<0.01)。杏灵分散片组患者TNF-α,IL-6及hs-CRP水平较常规治疗组下降明显。患者的超声心动图显示,左室收缩功能(LVEF)有一定的改善。结论杏灵分散片能抑制急性冠状动脉综合征患者的TNF-α,IL-6及hs-CRP表达,并对心功能有一定的改善作用。
Objective To evaluate the effects of Xingling Dispersible tablet on serum TNF-α,IL-6,high sensitive C reactive protein(hs-CRP) and cardiac function in patients with acute coronary syndrome(ACS). Methods A total of 126 patients diagnosed ACS by coronary angiography were randomly divided into conventional group(treated by conventional therapy) and treatment group(treated by conventional therapy combined with Xingling Dispersible tablet).Serum TNF-α,IL-6 and hs-CRP were measured before and after treatment.Left ventricular ejection fraction(LVEF) was evaluated by echocardiography before and after treatment. Results Compared with conventional group,the serum levels of TNF-α in treatment group[(10.36±3.56)ng/L vs.(16.21±4.87)ng/L],IL-6[(70.38±18.23)ng/L vs.(189.23±95.39)ng/L] and hs-CRP[(1.75±0.86)mg/L vs.(7.21±3.02)mg/L] were significantly decreased(all P0.01) and LVEF was significantly higher(P0.05) than. Conclusions Xingling Dispersible tablet can inhibit the inflammatory factors and improve cardiac function in patients with ACS.
出处
《中国心血管杂志》
2012年第5期361-363,共3页
Chinese Journal of Cardiovascular Medicine