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杏灵分散片对急性冠状动脉综合征患者炎症因子的表达和心功能的影响 被引量:3

Effects of Xingling Dispersible tablet on inflammatory factor and cardiac function in patients with acute coronary syndrome
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摘要 目的探讨早期应用杏灵分散片治疗对急性冠状动脉综合征患者血清TNF-α,IL-6及hs-CRP表达及心功能的作用。方法纳入经冠状动脉造影证实的急性冠状动脉综合征患者126例,用随机数字表简单随机化方法分为常规治疗组和杏灵分散片组,常规治疗组口服阿司匹林、β受体阻断剂、单硝酸异山梨醇酯、氯吡咯雷、阿托伐他汀等治疗,杏灵分散片组在常规治疗的基础上给予杏灵分散片1片,每日3次。所有患者行超声心动检查,测定左心室射血分数(LVEF),评价心功能。观察治疗前和治疗后12周,患者血清TNF-α、IL-6、hs-CRP水平和LVEF的变化,结果治疗前两组TNF-α、IL-6、hs-CRP、LVEF水平比较差异无统计学意义。与治疗前相比,杏灵分散片组患者治疗12周后,血清TNF-α[(10.36±3.56)ng/L比(16.21±4.87)ng/L]、IL-6[(70.38±18.23)ng/L比(189.23±95.39)ng/L]及hs-CRP[(1.75±0.86)mg/L比(7.21±3.02)mg/L]的水平都有了进一步的降低(均为P<0.01)。杏灵分散片组患者TNF-α,IL-6及hs-CRP水平较常规治疗组下降明显。患者的超声心动图显示,左室收缩功能(LVEF)有一定的改善。结论杏灵分散片能抑制急性冠状动脉综合征患者的TNF-α,IL-6及hs-CRP表达,并对心功能有一定的改善作用。 Objective To evaluate the effects of Xingling Dispersible tablet on serum TNF-α,IL-6,high sensitive C reactive protein(hs-CRP) and cardiac function in patients with acute coronary syndrome(ACS). Methods A total of 126 patients diagnosed ACS by coronary angiography were randomly divided into conventional group(treated by conventional therapy) and treatment group(treated by conventional therapy combined with Xingling Dispersible tablet).Serum TNF-α,IL-6 and hs-CRP were measured before and after treatment.Left ventricular ejection fraction(LVEF) was evaluated by echocardiography before and after treatment. Results Compared with conventional group,the serum levels of TNF-α in treatment group[(10.36±3.56)ng/L vs.(16.21±4.87)ng/L],IL-6[(70.38±18.23)ng/L vs.(189.23±95.39)ng/L] and hs-CRP[(1.75±0.86)mg/L vs.(7.21±3.02)mg/L] were significantly decreased(all P0.01) and LVEF was significantly higher(P0.05) than. Conclusions Xingling Dispersible tablet can inhibit the inflammatory factors and improve cardiac function in patients with ACS.
出处 《中国心血管杂志》 2012年第5期361-363,共3页 Chinese Journal of Cardiovascular Medicine
关键词 急性冠状动脉综合征 淋巴毒素-α 受体 白细胞介素6 Acute coronary syndrome TNF-α IL-6 High sensitive C reactive protein
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