国家基本药物致儿童药物不良反应237例报告分析

Analysis of 237 ADR Reports of Essential Drugs in Children

目的:了解国家基本药物致儿童药品不良反应(ADR)情况,促进儿科合理用药。方法:对百色市ADR监测中心2011年406例儿童ADR报告中涉及国家基本药物所致的237例ADR报告,按性别、年龄、给药途径、报告类型、基本药物类别、ADR涉及器官或系统及临床表现等进行统计、分析。结果:3岁以下儿童ADR发生率最高,占44.73%;静脉给药方式是引发ADR的主要途径,占80.89%;以抗微生物药引发ADR最多,占66.67%;ADR最常见的临床表现为皮肤及其附件损害,占58.56%。结论:应重视基本药物致儿童ADR的报告和监测工作,以减少或避免ADR的发生,保障患儿用药安全。

Objective： To study the occurrence of adverse drug reactions （ADR） in children of essential drugs, and promote the rational clinical drug use. Methods： A total of 237 pediatric ADR cases in Baise Municipal ADR monitoring center during 2011 were analyzed statistically in respect of patients＇ age and sex, routes of administration, report variety, essential drug categories, organs and systems involved, clinical manifestations. Results： Of the 237 ADR cases, 44.73% occurred in patients aged below 3, 80.89% were induced via intravenous route, 66.67% by antimicrobial drugs, 58.56% had the same clinical manifestation skin and its appendages lesions. Conclusions： Importance should be attached to the reporting and monitoring of children ADR of essential drugs, to avoid the occurrence of ADR and ensure medication safety.