普瑞巴林联合神经阻滞对老年人急性带状疱疹神经痛的疗效

The therapeutic effect of pregabalin with nerve block on acute herpetic neuralgia in aged people

目的观察单用普瑞巴林与联合神经阻滞对老年人急性带状疱疹神经痛的疗效比较。方法急性带状疱疹神经痛患者分为普瑞巴林＋神经阻滞组（利多卡因复合曲安奈德）（PNB组，36例）和普瑞巴林组（P组，25例）。PNB组除口服普瑞巴林外，应用1％利多卡因及曲安奈德行肋间神经阻滞。观察治疗后第3、7、30、60、180天VAS评分（分别为VAS1、VAS2、VAS3、VAS4、VAS5），普瑞巴林日最大剂量及不良反应。结果患者VAS1、VAS2、VAS3、VAS4、VAS5，评分PNB组均低于P组，（分别为P〈0．05，P〈0．001）。治疗后第30、60及180天患者疼痛消失比例PNB组均高于P组，（P〈0．05）。普瑞巴林日最大剂量两组问差异无统计学意义（P〉0．05）。两组患者均未出现严重不良反应。结论普瑞巴林联合神经阻滞治疗急性带状疱疹神经痛及降低带状疱疹后神经痛发病率的疗效优于单纯普瑞巴林。

Objective To investigate the effects of pregabalin alone and combination of pregabalin with nerve block on acute herpetic neuralgia （AHN）. Methods 61 AHN elderly patients were divided into pregabalin plus nerve block （ lidocaine with triamcinolone acetonide ） group （PNB group, n = 36） and pregabalin group （P group, n =25）. VAS was evaluated at3, 7, 30, 60and 180 days after treatment （VAS1, VAS2, VAS3, VAS4 andVAS5, respectively）. The dailymaximum doses of pregabalin and adverse reactions of the patients in each group were investigated. Results The scores of VASI, VAS2, VAS3, VAS4and VAS5 of the patients were significantly lower in NPB group than in P group （P 〈 0.05, P〈 0.001, respectively）. The incidence of complete relief of patients＇ pain was significantly higher in PNB group than in P group （P 〈 0.05）. The daily maximum doses of pregabalin was no significant differences in the two groups （P 〉 0.05）. No serious adverse reactions were observed in the two groups. Conclusion Pregabalm plus nerve block m combination with triamci- nolone acetonide can significantly relieve AHN patients＇ pain and reduce the incidence of PHN than pregabalin alone.