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α-硫辛酸对糖尿病大鼠糖外周组织内UCP2 mRNA表达的影响及意义 被引量：1

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摘要 目的探讨α-硫辛酸对糖尿病大鼠血脂、血糖、FINS及骨骼肌、脂肪组织内UCP2 mRNA的影响及意义。方法 30只Wistar大鼠随机分为正常对照(NC)组、糖尿病对照(DC)组、α-硫辛酸治疗(LA)组。应用链脲佐菌素(STZ)单次腹腔注射造模。NC组、DC组每只给予生理盐水2 ml/d,LA组60 mg.kg-1.d-1腹腔注射共4 w。测定各组的体重、血糖、糖化血红蛋白(HbA1c)、血脂,并检测脂肪及骨骼肌组织内UCP2 mRNA、丙二醛(MDA)、总抗氧化能力(T-AOC)的水平。结果 DC组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、HbA1c、胰岛素水平显著高于NC组,而高密度脂蛋白(HDL)水平显著下降,较NC组有显著性差异(P<0.05);LA组大鼠血浆TG、TC、LDL、HbA1c、胰岛素水平均较DC组显著下降,而HDL显著升高(P<0.05)。DC组脂肪及骨骼肌组织内MDA及UCP2表达水平显著高于NC组,而T-AOC水平显著降低,LA组大鼠组织内MDA水平及UCP2表达均较DC组显著下降,而T-AOC显著升高(P<0.05)。结论α-硫辛酸干预可明显减少其肝脏、脂肪骨骼肌组织内UCP2表达,改善糖尿病机体的"糖脂毒性",并进一步改善氧化应激状态,提高机体的抗氧化能力。
作者 张梅 李萍 孙海玲 李艳英 班博
机构地区 济宁医学院附属医院内分泌科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第20期4451-4454,共4页 Chinese Journal of Gerontology
基金 济宁市科技局计划课题(济科字〔2008〕50号)
关键词 Α-硫辛酸 2型糖尿病 氧化应激 UCP2
分类号 R589.2 [医药卫生—内分泌]
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参考文献25

  • 1Bullen JW Jr,Ziotopoulou M,Ungsunan L,et al.Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypo-thalamic neuropeptides(J).Am J Physiol Endocrinol Metab,2004;287(4):E662-70.
  • 2Vettor R,Fabris R,Serra R,et al.Changes in FAT/CD36,UCP2,UCP3 and GLUT4 gene expression during lipid infusion in rat skeletal and heart muscle(J).Int J Obes Relat Metab Disord,2002;26(6):838-47.
  • 3Kukidome D,Nishikawa T,Sonoda K,et al.Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxy-gen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells(J).Diabetes,2006;55(1):120-7.
  • 4Yang RL,Le G,Li A,et al.Effect of antioxidant capacity on blood lipid metabolism and lipoprotein lipase activity of rats fed a high-fat diet(J).Nutrition,2006;22(11-12):1185-91.
  • 5Yang RL,Li W,Shi YH,et al.Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress:a microarray analysis(J).Nutrition,2008;24(6):582-8.
  • 6Aubert J,Champigny O,Saint-Marc P,et al.Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells(J).Bio-chem Biophys Res Commun,1997;238(2):606-11.
  • 7Hjeltnes N,Fernstrm M,Zierath JR,et al.Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects(J).Diabe-tologia,1999;42(7):826-30.
  • 8Joseph JW,Koshkin V,Zhang CY,et al.Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet(J).Diabetes,2002;51(11):3211-9.
  • 9Lee SC,Robson-Doucette CA,Wheeler MB.Uncoupling protein 2 regu-lates reactive oxygen species formation in islets and influences suscepti-bility to diabetogenic action of streptozotocin(J).J Endocrinol,2009;203(1):33-43.
  • 10Krauss S,Zhang CY,Scorrano L,et al.Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction(J).J Clin Invest,2003;112(12):1831-42.

二级参考文献15

  • 1YongWU,Jing-pingOU-YANG,KeWU,YaWANG,Yun-fengZHOU,Chong-yuanWEN.Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B[J].Acta Pharmacologica Sinica,2005,26(3):345-352. 被引量：59
  • 2Klatt P,Esterbauer H.Oxidative hypothesis of artherogenesis[J].J Cardiovasc Risk,1996;3(4):346-51.
  • 3Ziegler D,Schatz H,Conrad F,et al.Effects of treatment with the antioxidant α-lipoic acid on cardiac autonomic neuropathy in NIDDM patients.A4-month randomized controlled multicenter trial (DEKAN Study).Deutsche Kardiale Autonome Neuropathie[J].Diabetes Care,1997;20(3):369-73.
  • 4Melhem MF,Craven PA,Derubertis FR.Effects of dietary supplementation of a-lipoic acid on early glomerular injury in diabetes mellitus[J].J Am Soc Nephrol,2001;12(1):124-33.
  • 5Sola S,Mir MQ,Cheema FA,et al.Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome:results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study[J].Circulation,2005;111(3):343-8.
  • 6Evans JL,Goldfine ID,Maddux BA,et al.Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction[J] ?Diabetes,2003;52(1):1-8.
  • 7Balkis BS,Othman F,Louis SR,et al.Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats[J].Rom Morphol Embryol,2009;50(1):23-30.
  • 8Vinayagamoorthi R,Bobby Z,Sridhar MG.Antioxidants preserve redox balance and inhibit c-Jun-N-terminal kinase pathway while improving insulin signaling in fat-fed rats:evidence for the role of oxidative stress on IRS-1 serine phosphorylation and insulin resistance[J].J Endocrinol,2008;197(2):287-96.
  • 9Butler JA,Hagen TM,Moreau R.Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion[J].Arch Biochem Biophys,2009;485(1):63-71.
  • 10Yang RL,Li W,Shi YH,et al.Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress:a microarray analysis[J].Nutrition,2008;24(6):582-8.

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中国老年学杂志
2012年 第20期

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