综合疗法治疗复发性儿童喉乳头状瘤

Combined therapy for juvenile recurrent laryngeal papilloma

目的 探讨手术切除联合局部注射麻疹疫苗及肌肉注射α—干扰素的综合治疗方法对儿童复发性喉乳头状瘤（JRLP）的疗效。方法将46例喉乳头状瘤患儿分为两组，其中综合治疗组26例，均在支撑喉内镜下采用喉旋切技术治疗，并在肿瘤基底部注射麻疹疫苗（1支麻疹疫苗用注射用水1 mL溶解，0.3 mL/次），自术后第15天开始肌肉注射α—干扰素，每次100万单位，隔日1次，疗程3个月。对照组20例，均经手术切除肿瘤。结果对所有患儿随访1年，综合治疗组26例中，有效20例；对照组20例中，有效8例。结论手术切除联合局部注射麻疹疫苗及肌肉注射αα—干扰素，是儿童复发性喉乳头状瘤的有效治疗方法，较单纯手术治疗疗效更好。

Objective To explore the effects of surgical ablation combined with local injection of measles vaccine and intramuscularctinterferon for juvenile recurrent laryngeal papilloma（JRLP）. Methods 46 children who had laryngeal papilloma were divided into two groups ,the combined therapy group 26 patients received Powered Laryngeal Shaver treatment under suspensive laryngoscope, and were injected measles vaccine in the basal of tumor（ A measles vaccine dissolved in water for injection 1ml,0, 3 ml each）. 15 days after the surgery they began to receive intramuscular injection of a-interferon（ 1 million units intramuscularly every other day for 3 months as a course） ,the control group 20 children took operations to remove tumor only. Results After one year follow-up,20 children in the combined therapy group showed a significant effect,compared with 8 in the control group. Conclusions Surgical ablation combined with local injection of measles vaccine and intramuscular interferon for juvenile recurrent laryngeal papilloma （JRLP） showed a significant effect compared with operations only.