SOX7基因在乳腺癌中的研究进展

Research advances of SOX7 gene in breast cancer

在乳腺癌等一些人类肿瘤的研究中发现，SOX7基因极有可能是一个抑癌基因。SOX7基因抑癌作用的机制可能是通过调节Wnt／β-catenin信号通路介导的转录过程来完成的，而异常的Wnt／β-catenin信号通路则有可能通过调控其下游的靶向基因Cyclin D1等来发挥其作用，使细胞的异常增生活动无法进行下去，从而发挥其肿瘤抑制的功能。本文就目前乳腺癌中SOX7基因的作用及其与之密切相关的β-cate—nin、Cyclin D1基因的研究现状作一综述。

Study found that in some human tumors such as breast cancer, SOX7 gene is highly likely to be a tumor suppressor gene. The tumor suppressor role of SOX7 may be accomplished by regulating the Wnt/β-catenin signaling pathway mediated the transcription process, and the abnormal Wnt/β-catenin signaling pathway is likely to play its role through the regulation of its downstream target gene Cyclin D1, etc, so that the abnormal cell proliferation activity is unable to carry on, and thus plays the function of tumor suppressor. This review will summarize the research progress of the role of SOX7 gene and its closely related β-catenin, Cyclin D1 gene in breast cancer.