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多潜能干细胞定向分化为胰腺β细胞的研究进展 被引量：1

Research progress in generating pancreatic 13 cells from pluripotent stem cells
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摘要 近几年利用多潜能干细胞体外诱导分化为胰岛β细胞的研究进展迅速。本文主要讨论近几年来维甲酸、骨形态发生蛋白、成纤维生长因子家族在多潜能干细胞分化为胰岛β细胞过程中的作用及其可能机制方面的研究进展，以及多潜能干细胞于体外诱导分化为胰岛β细胞的不同阶段其表面抗原CD14、CD49e、CD238、CD24、上皮细胞表面黏附分子阶段特异型胚胎抗原1和3的表达与分化的关系及组蛋白去乙酰化酶抑制剂诱导小分子1和2、间变性淋巴瘤激酶的抑制物1和2在分化中的作用。 Efforts have been directed at the development of efficient protocols for the differentiation of pluripotent stem cells into pancreatic β-cells. This review focuses on the mechanism of RA, BMP, FGFs, IDE1, IDE2, ALK- i 1 and ALK1-2 during the process in which pluripotent stem cells differentiate to pancreatic β-cells and the relationship between the differentiation and the expression of the surface markers including CD14, CD49e, CD238, CD24, EpCAM, SSEA3 and SSEA1 in the different stage of this process.
作者 张钰 宋陆军
机构地区 复旦大学附属中山医院普外科
出处 《国际外科学杂志》 2012年第10期701-704,共4页 International Journal of Surgery
关键词 多潜能干细胞 细胞分化 胰岛Β细胞 Pluripotent stem ceils Cell differentiation Pancreatic β-cell
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
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参考文献24

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二级参考文献2

同被引文献22

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国际外科学杂志
2012年 第10期

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