摘要
目的观察复方木尼孜其对女性迟发性痤疮血清睾酮的影响及疗效。方法将128名痤疮患者随机分为两组。治疗组(A组)65例口服复方木尼孜其颗粒。对照组(B组)63例口服一清胶囊和维生素B6,治疗时间为28 d。另设62例相应年龄段非痤疮患者作对照组(C组)。于治疗前后采用电化学发光免疫分析法检测其卵泡期血清睾酮水平,并进行疗效评价。结果 A组和B组的总有效率分别为89.2%和61.9%,差异有统计学意义(P<0.05)。A组治疗前血清睾酮水平较C组明显升高(P<0.05),而治疗后血清睾酮水平与C组相比差异无统计学意义(P>0.05)。结论女性迟发性痤疮发病的主要原因与雄激素分泌增多有关。复方木尼孜其颗粒具有抗雄激素作用,对女性迟发性痤疮的疗效确切,且无明显不良反应。
Objective To investigate influence and efficiency of compound Muniziqi granules on the serum levels of testosterone in late-onset female patients with acne.Methods 128 late-onset female patients with acne were randomly divided into two groups.65 patients in treatment group(group A) were given compound Muniziqi granule;60 patients in control group(group B) were given Yiqing capsule and vitamin B6,the treatment time was 28d.After 4 weeks the therapeutic effect analysis was taken after the therapy.Another 62 cases of non-acne patients with corresponding age were selected as the control group(group C).For group A and B,we also detected the levels of serum testosterone by electrochemiluminescence immunoassay before and after the treatment,the efficiency was evaluated.Results The total effective rate of group A and control group B were 89.2% and 61.9%.There was statistical difference between the two groups(P0.05).The serum level of testosterone before the treatment was significantly higher than that of the normal controls(P0.05).Compared with group C,no significant statistical difference was found in the serum levels of testosterone after the treatment(P0.05).Conclusion The main pathogenesis of late-onset acne in female patients is the increasing of the level of serum testosterone.Compound Muniziqi granule has the impact of anti-androgen and it is effective and safe in treatment of late-onset female patients with acne,no obvious side effects were observed.
出处
《临床军医杂志》
CAS
2012年第5期1161-1163,共3页
Clinical Journal of Medical Officers
关键词
女性
痤疮
复方木尼孜其
睾酮
woman
acne
compound Muniziqi granule
testosterone