干扰素α-1b和聚乙二醇α-2a对视网膜病变的临床观察

Clinical observation of retinopathy occurrence after using IFN α-1b and pegylated IFN α-2a

目的观察我院住院患者使用IFNα-1b和聚乙二醇IFNα-2a注射剂不良反应视网膜病变发生的情况。方法随机抽取2010年1月至2011年12月我院住院患者48例分成A、B组,A组25例使用IFNα-1b(主要为儿科手足口病病例),B组23例为感染科慢性乙肝和丙肝病例,使用聚乙二醇IFNα-2a,观察两组病例用药后视网膜病变发生情况。结果 A组没有出现1例视网膜病变;B组仅1例患者在住院期间出现稍结膜充血。结论我院住院患者使用IFNα-1b和聚乙二醇IFNα-2a注射剂视网膜病变发生的情况仍属罕见。

Objective To observe adverse reactions of inpatients with IFN α-1b and pegylated IFNα-2a injections about retinopathy.Methods The article randomly chose 48 cases of inpatients from January 2010 to December 2011,and put them into A,B group.A group of 25 cases were used IFN α-1b（mainly for the pediatric cases of hand-foot and mouth disease）;B group of 23 cases were chronic hepatitis B and C in infectious dept,and were used pegylated IFN α-2a;Finally the article observed retinopathy occurrence of two groups of cases after drug.Results There was no case of retinopathy in A group;Only one patient of B group had slightly conjunctiva hyperaemia during hospitalization.Conclusion In the course of using IFN α-1b and pegylated IFNα-2a injections,retinopathy occurrence of our hospital inpatients is rare.