新疆阿克苏地区库车县乳母口服碘油胶丸前后母子尿碘营养状况调查

Urine Iodine Levels of Lactating Mothers and their Children Living in Kuche County of Akesu District before and after Taking Iodine-oil Pills

目的了解阿克苏地区库车县重点人群的碘营养状况,以及服用碘油丸后的变化情况,为今后在阿克苏地区对重点人群口服碘油胶丸提供指导意见。方法在新疆阿克苏地区库车县牙哈镇的四村选择109名近半年内未服用过碘油丸的19～36岁哺乳期妇女及其子女(20 d～18个月婴幼儿),采用现场干预的方法,并于服药后的第1、3、7、14、30、50、75、100 d分别采集尿样,同时采集婴幼儿干预组及对照组尿样,用过硫酸铵消化—砷铈催化分光光度法分析碘含量。结果阿克苏地区库车县牙哈镇的四村乳母109人,干预组和对照组基础尿碘的中位数为136.54μg/L和114.90μg/L,尿碘含量<100μg/L者分别占39.80%和42.00%,<200μg/L者分别占68.66%和70%。子女109人,干预组与对照组基础尿碘中位数为251.45μg/L和260.75μg/L;<100μg/L者分别占15.30%和10.00%;补碘干预可提高乳母及其子女的尿碘水平。结论通过乳母口服200 mg碘油丸后,以期达到纠正和改善缺碘者的碘营养状况,消除新生儿碘缺乏病的发生,保证脑细胞和智力的正常发育。

Objectives To investigate the nutritional state of iodine in lactating mothers and their infants in Kuche County, Akesu District and the change of urine iodine levels after taking iodine-oil pills in order to provide theoretical basis for guiding the supply of iodine-oil pill in key population. Methods A total of 109 pairs of lacta- ting women and their children （20-day to 18-month of age） not taking iodine pills for half a year from 4 villages were selected to carry out an on-site interventional investigation. Urine samples of mothers and their infants collect- ed at the 1 st, 3rd, 7th, 14th, 30th, 50th, 75th and 100thday after taking the pills in the experimental group and not tak- ing the pills in the control group were digested by ammonium persulfate and iodine levels were detected by arsenic ce- rium catalytic spectrophotometry, respectively. Results The median of urine iodine of mothers in the intervention group and control group was 136. 54μg/L and 114. 90μg/L; 39.80% and 42. 00% of them were 〈 100 μg/L and 68.66% and 70.00% of them were 〈200 μg/L, respectively. The medium of urine iodine for children in the in- tervention group and control group was 251.45μg/L and 260. 75μg/L; 15.30% and 10.00% of them were〈 100μg/L, respectively. The intervention with iodine-oil pills can improve the iodine levels of mothers and chil- dren. Conclusions It is a feasible and good way of providing iodinated oil pills for lactating mothers to improve the iodine nutritional status and to ensure the normal brain development of infants.