摘要
非达霉素作为新型的大环内酯类抗生素,用于艰难梭菌感染的治疗。本文对非达霉素的化学结构、药理机制、抗菌活性、耐药机制、药动学性质、临床研究等方面作一综述。
Fidaxomicin is the antibiotic with a novel structure of macrolides for the treatment of Clostridium difficile infection.In this paper,the chemical structure,pharmacological mechanism,antibacterial activity,resistance mechanisms,pharmacokinetics and clinical trials of fidaxomicin were reviewed.
出处
《药学与临床研究》
2012年第5期419-424,共6页
Pharmaceutical and Clinical Research
关键词
非达霉素
艰难梭菌感染
作用机制
药动学
临床研究
Fidaxomicin
Clostridium difficile infection
Mechanism
Pharmacokinetics
Clinical trials