摘要
目的:优选半乳糖化羧甲基壳聚糖磁性纳米载体(galactosylated-carboxymethyl chitosan-magnetic iron ox-ide nanoparticles,Gal-CMCS-Fe3O4NP)的制备条件。方法 :采用正交分析试验方法 ,以Fe3O4NP与羧甲基壳聚糖(car-boxymethyl chitosan,CMCS)质量比、pH值和搅拌时间为考察因素,纳米载体的粒径和磁响应性为考察指标。结果 :Fe3O4NP与CMCS的质量比为1∶2、pH值为7、搅拌时间为1 h时为最佳制备条件,最终所制备的Gal-CMCS-Fe3O4NP的平均粒径为20 nm,具有较好的磁响应性。结论:获得较满意的Gal-CMCS-Fe3O4NP的制备条件,纳米载体性状符合要求。
Objective: To optimize the preparing condition of galactosylated-carboxymethyl chitosan-magnetic iron oxide nanoparticles(Gal-CMCS-Fe3O4NP).Methods: Orthogonal experiment was designed with the particle diameter and magnetic property as index,and with quality ratio between Fe3O4NP and carboxymethyl chitosan(CMCS),pH and the stirring time as factors.Results: The orthogonal analysis indicated that the optimal preparation conditions was followed,quality ratio between Fe3O4NP and carboxymethyl chitosan(CMCS) was 1∶2,pH was 7 and the stirring time was 1 hour.The final Gal-CMCS-Fe3O4NP have good magnetic property,and the average particle diameter is 20 nm.Conclusion: With this method,a satisfactory preparing condition can be obtained,and the character of the nanoparticles is desirable.
出处
《南通大学学报(医学版)》
2012年第5期350-352,共3页
Journal of Nantong University(Medical sciences)
基金
国家自然科学基金青年基金资助项目(81000984)
江苏省高校自然科学研究面上资助项目(10KJB320014)
南通市社会发展科技计划资助项目(S2010019)
江苏省"六大人才高峰"资助项目(2011-WS066)
关键词
正交试验
磁性纳米粒子
羧甲基壳聚糖
半乳糖
orthogonal test
magnetic nanoparticles
carboxymethyl chitosan
galactose