134例宫颈上皮内瘤变患者HPV分型检测结果分析

Study on the types of human papillomavirus of 135 cases in cervical intraepitheliai neoplasia and cervical carcinoma

目的探讨宫颈上皮内瘤变(CIN)中不同类型人乳头瘤病毒(HPV)的感染及分型情况。方法回顾性研究北京军区总医院妇科门诊134例已经确诊的CIN患者,采用凯普的核酸分子快速导流杂交基因芯片技术对HPV进行分型。结果 1.各级别CIN以HPV高危亚型单一或者多重感染为主;2.在HPV阳性的101例患者中,单一感染者73例(72.28%),双重感染者24例(23.76%),三重感染者3例(2.97%),四重感染者1例(0.99%);3.HPV-16、58感染率最高,分别为30.83%,24.06%。结论 HPV感染以高危型和多重感染为主;随CIN级别的增高,HPV阳性率也是增高的;HPV-16亚型的感染率最高。

Objective： To study the infection condition of different types of Human papiUoma virus in cervical intraepithelial neoplasia （CIN）. Methods： A total of 134 gynecological outpatients in The Military General Hospital of Beijing who were confirmed to have CIN were studied, The HybriMax were used to detect HPV genotypes. Results： 1. All levels of CIN is main infected with single or multiple high risk HPV genotypes. 2. In 102 HPV positive patients, single infected patients is 74 cases （72. 28% ）, double infected patients is 24 cases （23, 76% ）, triple infected patients is 3 cases （2. 97% ）, quadruple patients infected is 1 case （0. 99% ） ; 3. The infected rate of HPV - 16, 58 is the hightest, 30. 83% and 24. 06% respectively. Conclusion： The main infected HPV is the high risk and mul- tiple genotypes, As the CIN types increaseing, the positive HPV is increasing too. The infection of HPV - 16 types is the highest.