Rh(D)阴性孕妇血清抗-D水平检测意义

Significance of detection the anti-D level of Rh(D)-negative pregnant women

目的了解Rh(D)阴性孕妇抗-D抗体水平及与婴儿预后的关系。方法分析2004年1月～2010年12月194例Rh(D)阴性孕妇的妊娠、分娩及其IgG抗-D效价。结果 194例Rh(D)阴性孕妇中有19例产生了抗-D抗体,IgG抗体效价从1∶2-1∶2048不等,其中妊娠≤2胎次9例,抗-D效价从1∶2-1∶128,妊娠≥3胎次7例(其中3例孕妇未在本院生产,故未统计在内)。抗-D效价从1∶128-1∶2048。其中有1例曾输过血的孕妇第1胎产生了抗-D。结论对Rh(D)阴性孕妇抗-D抗体的检测,根据抗体效价及时采取相应的预防及治疗措施,可明显改善围产儿预后。

Objective ： To comprehend the correlation between anti - D level of Rh （ D ） - negative pregnant women and baby prognostic. Methods： The clinical data of 194 Rh （D） -negative pregnant women during 2004. 1 to 2010. 12 was analyzed including gestation, delivery and their anti- D level. Results： Among 194 pregnant women of Rh （D） negative 19 cases show anti -D, anti- body level of IgG from 1 ： 2 - 1 ： 2048, there are 9 pregnant women with two and less pregnancy whose, antibody level of IgG from 1： 2 - 1： 128, there are 7 cases with three and more pregnancy whose antibody level of IgG from 1 ： 128 - 1 ： 2048. （ Three pregnant women haven＇t given birth in our hospital are not conclued）. One case of them produced anti - D who are the 1 gestation and once transfusional. Conclusion ： Detecting anti - D level in pregnant women with Rh （D） negative, adopting prevent therapeutic measure in time can improve newborn prognosis and according the anti - Rh （D） level of antibody.