阿扎司琼联合氟哌利多预防妇科腹腔镜手术后恶心呕吐

Clinical research of azasetron combined with droperidol in the prevention of gynecological laparoscopic postoperative nausea and vomiting

目的分析阿扎司琼联合氟哌利多在预防妇科腹腔镜手术后恶心、呕吐中的临床疗效。方法88例妇科行腹腔镜手术患者，随机分为A、B、C、D组，每组22例。麻醉诱导前10rain分别静脉注射生理盐水、氟哌利多、阿扎司琼、阿扎司琼＋氟哌利多。观察患者术后24h恶心、呕吐发生率，记录术后24h内第1次出现恶心的时间。结果B、C组恶心、呕吐发生率低于A组，D组恶心、呕吐发生率低于B、C组，但差异无统计学意义（P〉0．05）。D组恶心、呕吐发生率为4．5％，明显低于A组（36．4％，P〈0．05）。B、C、D组初次恶心时间明显长于A组（19〈0．05），D组初次恶心时间明显长于B、C组（P〈0．05）。结论麻醉诱导前静脉注射阿扎司琼或氟哌利多均能有效预防手术后恶心呕吐，两药联合应用效果更好。

Objective To investigate the clinical efficacy of the azasetron combined with droperidol in the prevention of gynecological laparoscopic postoperative nausea and vomiting. Methods 88 cases of gynecologic laparoscopic surgery patients, which were randomly divided into group A, B, C, D, 22 cases in each group. 10 min before the induction of anesthesia, injected intravenously with saline, droperidol, azasetron, azasetron combined with droperidol in group A, B, C, D. After surgery, the rate of nausea and vomiting were observed within 24 h, first time of nausea within 24 h was recorded. Results The rate of nausea and vomiting in group B and C was lower than in group A, the rate of nausea and vomiting in group D was lower than in group B and C, but the difference was not statistically significant （ P 〉 0.05 ）. In group D, the rate of nausea and vomiting was 4.5% , significantly lower than group A （36.4%） （ P 〈 0.05 ）. In group B and D, the first time of nausea was significantly longer than group A （ P 〈 0.05 ）. The first time of nausea in group D was significantly longer than group B and C （P 〈 0.05 ）. Conclusion Before the induction of anesthesia, intravenous injection azasetron or droperidol can effectively prevent postoperative nausea and vomiting. Combination of two drugs is better.