艾滋病感染者/患者合并感染乙肝病毒、丙肝病毒、梅毒的检测与分析

Detection and Analysis of Co-infection with HBV,HCV or Treponema Pallidum in HIV/AIDS patients

目的通过实验室检测146例艾滋病感染者/患者(HIV/AIDS)合并感染乙肝病毒(HBV)、丙肝病毒(HCV)、梅毒螺旋体(TP)的状况及多重感染对HIV/AIDS的影响,为HIV/AIDS的防控和综合治疗提供科学依据。方法采用酶联免疫法(ELISA)检测HIV/AIDS血液中HBV、HCV、TP的相应抗体;用流式细胞仪检测HIV感染者全血中的CD4/CD8细胞,检测结果分组,组间比较采用卡方检验。结果 146例HIV/AIDS合并HCV感染98例,感染率(67.12%);合并梅毒感染47例,感染率(32.19%);合并HBV感染33例,感染率(22.60%)。122例多重合并感染者发病74例,发病率60.66%;单纯HIV感染者24例,发病5例,发病率20.83%。结论 HCV是HIV/AIDS常见合并感染的病原体,在其治疗的同时要做好护肝保肝的工作,综合治疗。

Objective To test hepatitis B virus（HBV）,hepatitis C virus（HCV） and Treponema pallidum（TP） in 146 HIV/AIDS patients and to analyze the impacts of the co-infections,so as to provide a scientific basis for the prevention,control and comprehensive treatment of HIV/AIDS. Methods The antibodies of HBV,HCV and TP were detected in the blood from 146 HIV/AIDS patients by enzyme-linked immunosorbent assay（ELISA）.The CD4/CD8 cells in the whole blood of the patients were determined by flow cytometry.The patients were grouped according to their detection results.The data were compared among the groups by chi-square test. Results Among 146 HIV/AIDS patients,98,47 and 33 cases were co-infected with HCV,TP and HBV respectively,with a co-infection rate of 67.12%,32.19% and 22.60%.Among the 122 cases with co-infection,74 progressed into AIDS,with a morbidity rate of 60.66%.However,for the 24 patients with simple HIV infection,only 5 got AIDS,with a morbidity rate of 20.83%. Conclusions HCV is the commonest co-infection pathogen for HIV/AIDS.It is of great importance to protect the liver during HIV/AIDS treatment.