摘要
目的评价扁桃体切除术联合激素对IgA肾病的疗效。方法选取42例经肾活检诊断为IgA肾病患者,分为扁桃体切除术联合激素治疗组24例和单用激素治疗组18例。经12个月治疗后,评估扁桃体切除联合激素治疗方法对IgA肾病的疗效。结果经过12个月的治疗,尿蛋白转阴率联合治疗组为79.2%,高于单用激素治疗组的44.4%(P=0.020),尿潜血转阴率联合治疗组为75.0%,高于单用激素治疗组的16.7%(P<0.001),尿异常转阴率联合治疗组为62.5%,高于单用激素组的16.7%(P=0.003)。结论扁桃体切除联合激素治疗对IgA肾病具一定疗效。
Objective To evaluate how tonsillectomy plus steroid therapy affects IgA nephropathy in patients.Methods A total of 42 patients were enrolled into 2 groups： 24 cases in tonsillectomy plus steroid therapy group,and 18 cases in steroid therapy group.Oral prednisolone was given at the dose of 1 mg/kg/d for two months,reduced by 5 mg per half a month,and then reduced to 5 mg/d of maintaining.From 7th month,prednisolone was given at the dose of 5 mg/d for 6 months.Serum creatinine levels were compared,and ratios of urinary protein and/or occult blood between the groups were determined.Results After 12 months,the ratio of the urinary protein in tonsillectomy plus steroid therapy group was higher than that in steroid therapy group（P=0.020）;occult blood disappeared more in tonsillectomy plus steroid therapy group than in steroid therapy group（P0.001）;remission of urinary abnormalities were also higher in combined therapy group.Conclusion Tonsillectomy plus steroid therapy can raise clinical remission rate and has beneficial effects on patients with IgA nephropathy.
出处
《安徽医学》
2012年第9期1160-1163,共4页
Anhui Medical Journal
