T细胞免疫球蛋白粘蛋白域基因多态性与哮喘关系的研究进展

Advance in the relationship between TIM gene family polymorphism and asthma

哮喘是儿童时期最常见的慢性呼吸道变应性疾病,近些年来在全球范围有逐渐增加的趋势。大多数成年期哮喘由儿童哮喘发展而来,其病因既受环境因素的影响,又有明显的遗传倾向,是一种复杂的多基因遗传性疾病。人类的TIM基因家族有3个,即:TIM-1、TIM-3和TIM-4,定位于染色体5q33.2,此区域是哮喘的主要遗传易感位点之一。本文就TIM基因家族多态性与哮喘近年来的研究进展做一综述。

Asthma is the most common chronic respiratory allergic disease in childhood, and in recent years it has spread worldwide. Asthma is a complex disease of multifactorial etiologies, including environmental factors and obvious genetic elements. Researchers also found that the prevalence of asthma reported in various countries and regions have great differences. One of the major genetic susceptibility sites for asthma is chromosome 5q33.2, on which TIM gene family has been found including TIM-l, TIM-2, and TIM-3. This is also one of the major genetic susceptibility sites for asthma. The article is to summarize the progress of the researches on the TIM gene family polymorphisms and asthma in recent years.