水飞蓟宾联合吡格列酮治疗非酒精性脂肪性肝病76例疗效观察

The Combinative Treatment with Silibinin and Pioglitazone on 76 Cases Non-alcoholic Fatty Liver Disease

目的观察在饮食控制、适量运动基础上,水飞蓟宾联合吡格列酮治疗非酒精性脂肪性肝病(NAFLD)的临床疗效。方法将76例非酒精性脂肪性肝病患者随机分为2组。对照组予饮食控制,进行中等量有氧运动,给予口服吡格列酮,时间为12周;治疗组在对照组基础上加服水飞蓟宾。结果治疗组总有效率为80.95%,对照组总有效率为61.76%。治疗组总有效率明显高于对照组(P<0.05)。结论在饮食控制和适量运动的基础上,水飞蓟宾联合吡格列酮治疗NAFLD具有较好的临床疗效。

Objective. To inyestgate the effect of silibinin combined pioglitazone in treatment of non-alcoholic fatty livet disease（NAFLD）. Methods 76 NAFLD patients were divided into two groups randomly. Patients in control group were given diet contrding and moderate aerobic exercise, and pioglitazone orauy for 12 weeks. Based on control group,treatment group,in- creased silibinin. Results The general effective rate in treatment group （ 80.95% ） was markedly higher than in control group （61.76%）. Conclusion Based on diet and exercise, silibinin combined pioglitazone in treatment of NAFLD was safe and highiy effective .