增殖型坏疽性脓皮病并发骨髓异常增生综合征2例

Proliferative pyoderma gangrenosum complicated by myelodysplastic syndrome;Two case report

报告2例增殖型坏疽性脓皮病(pyoderma gangrenosum)并发骨髓异常增生综合征(myelodysplastic syndrome,MDS)。2例患者均为男性,病程分别为2年和3个月,经实验室检查、组织病理检查、骨髓活检、染色体检查确诊为增殖型坏疽性脓皮病并发骨髓异常增生综合征。对诊断为坏疽性脓皮病的患者,应当仔细检查是否有潜在的并发疾病,特别要进行血液学检查。并发骨髓异常增生综合征的增殖型坏疽性脓皮病预后较差。1例发病后18个月死于骨髓异常增生综合征,1例正在随访中。

Two cases of proliferative pyoderma gangrenosum complicated by myelodysplastic syndrome （MDS） are reported. Both patients were male, with 2 years and 3 months of disease course respectively. One patient died of MDS after 18 months of disease onset, and the another patient was still following up. Patients diagnosed as pyoderma gangrenosum should be examined carefully for systemic complications, especially need to perform the hematological tests. These patients have poor prognosis if complicated by myelodysplastic syndrome.