注射性臀部异位骨化症4例报告

A report of 4 cases about gluteal heterotopic ossification caused by injection

目的:探讨注射性臀肌骨化症的发病机制与治疗。方法:自2006年4月至2011年5月采用手术方法治了疗4例注射性臀部异位骨化症患者,均为老年女性,年龄67～76岁,平均71岁;均为双侧患病,表现为双侧臀部疼痛,可用手触及结节状物,质硬;X线、CT、病理检查均符合异位骨化症表现。其中2例采用全部切除骨化组织加局部挛缩粘连软组织松解,另2例采用部分切除加局部软组织松解。结果:术后所有患者伤口愈合良好,无并发症发生。所有患者均获随访,时间2～64个月,平均26个月。患者切除部位可触及肿块及疼痛均消失。结论:注射性臀部异位骨化症是注射苯甲醇等药物后发生在成年人的药物性反应,部分或全部切除痛性肿块、松解局部臀肌筋膜等软组织是治疗该病的关键。

Objective：To study the pathogenesis and treatment of gluteal heterotopic ossification caused by injection. Methods：From April 2006 to May 2011,4 old female patients with gluteal heterotopic ossification caused by injection were treated by resection. The average age was 71 years old ranging from 67 to 76. The illness were bilateral,the clinical character was pain and hard nodules in the both hip. The X-ray,CT and pathology matched the diagnosis of heterotopic ossification. Two of them were treated by totally removing the ossified tissues,and loosing the spastic and adhesive soft tissues. The other two were treated with local resection and soft-tissue lysis. Results：The wound of all patients healed well,and there were no complication. All patients were followed-up from 2 to 64 months（averaged 26 months）. There were no lump and pain in the location of surgical resection. Conclusion：Gluteal heterotopic ossification caused by injection is the drug reaction produced by injecting benzyl alcohol or other drugs,and happens in adults. The key for the treatment is to remove part or all of the painful lump,and loose the local fascia and other soft tissues of the gluteal muscles.