关节腔内用药治疗膝关节骨关节炎的探讨

Investigation of articular cavity medicating for treatment of knee osteoarthritis

骨性关节炎是中老年常见的一种慢性进行性骨关节炎。目前药物治疗膝关节骨性关节炎的方法很多,其中关节腔内注射属于局部用药,能直接作用于关节炎,是骨关节炎治疗中使用最多且最有效的方法之一。在单一用药的情况下可能存在发挥抗炎作用的同时诱发关节软骨的损伤,或者在促进关节软骨修复的同时抗炎作用不甚理想。因此最理想的治疗方法应该是综合分析患者的关节结构、功能及可能的致病因子,了解患者期望关节恢复和使用程度等,来设计个体化的治疗计划。

Osteoarthritis （OA） is a common chronic progressing disease in the elderly. In current there are many methods of drug treatment for knee osteoarthritis,the intra-articular injection belongs to local application,can direct effect on arthritis,is the most used and most effective methods in osteoarthritis treatment. A single medication may exist that anti-inflammatory effects produce a marked effect but articular cartilage injury is induced,or articular cartilage repairing are promoted but anti-inflammatory effects is not ideal. Therefore,the best method of treatment should be a comprehensive analysis of articular structure,function and possible pathogenic factor to understand the expectations of level of recovery and use in patients to design an individualized treatment plan.