动脉粥样硬化性脑梗死患者血清C反应蛋白及血浆MMP-9的表达及意义

The expression and significance of CRP and MMP-9 in the atherothrombotic cerebral infarction

目的通过检测动脉粥样硬化性脑梗死患者血清C反应蛋白(hs-CRP),血浆基质金属蛋白酶-9(MMP-9)的水平以及血清中血脂相关指标,以探讨它们在脑梗死中的表达及意义。方法选择35例动脉粥样硬化性脑梗死患者为病例组,选择同期年龄、性别相匹配的健康体检者20例为对照组,用免疫比浊法测定血清hs-CRP水平,用酶联免疫吸附法测定血浆MMP-9水平,同时运用多普勒超声测定颈动脉内膜中层厚度(IMT),全自动生化仪测定血脂指标(TC,TG,LDL),采用NIHSS评分量表对患者进行神经功能缺损评分。结果动脉粥样硬化性脑梗死患者hs-CRP、MMP-9、TC、TG、LDL、IMT值均较对照组增高(P<0.05)。病例组hs-CRP、MMP-9水平均与NHISS评分相关,与TC、TG、LDL、IMT值无相关性。MMP-9与hs-CRP水平呈直线正相关。结论 MMP-9及hs-CRP可能参与了动脉粥样硬化性脑梗死的病理过程,可以提示病情的严重程度。

Objective To assess the significance of C-reactive protein （CRP） and matrix metalloprotein- ases-9 （MMP-9） by detecting the level of them in the atherothrombotic cerebral infarction. Methods Thirty- five patients were choosen for the cerebral infarction group and twenty healthy people for the control group . Using the ELASA method to measure the levels of MMP-9 in the plasma and immunoturbidimetric assay to de- tect the levels of CRP in the serum. The carotid intimal-medial thickness （IMT） was detected by a Color Doppler ultrasound system. TC,TG,LDL were measured respectively. The national institutes of health stroke scale （NIHSS） scores were evaluated when the patients had been admitted. Results The serum CRP levels and the plasma levels of MMP9 were significantly higher in the atherothrombotic cerebral infarction compared with the control group （P^0.05）. The IMT levels in the cerebral infarction were higher than those in the control group （P〈0.05）. The levels of CRP were correlated with the levels of MMP-9 and NIHSS （P〈0. 05）, but not correlated with age and the lipid levels （P〈0. 05）. Conclusions C-reactive protein and matrix metallopro- teinases-9 play an important role in the atherothrombotic cerebral infarction. They may predict the severity of atherothrombotic infarction.